1. Metabolic Enzyme/Protease
  2. SGK

SGK1-IN-1 

Cat. No.: HY-18607
Handling Instructions

SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.

For research use only. We do not sell to patients.

SGK1-IN-1 Chemical Structure

SGK1-IN-1 Chemical Structure

CAS No. : 1279829-87-6

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Description

SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.

IC50 & Target

IC50: 1 nM (SGK-1)[1][2].

In Vitro

SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3, with IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively. SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3876 mL 11.9380 mL 23.8760 mL
5 mM 0.4775 mL 2.3876 mL 4.7752 mL
10 mM 0.2388 mL 1.1938 mL 2.3876 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

418.83

Formula

C₁₇H₁₂ClFN₆O₂S

CAS No.

1279829-87-6

SMILES

O=S(C1=C(F)C=CC(Cl)=C1)(NC2=CC=C(C3=NC(NN=C4N)=C4N=C3)C=C2)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
SGK1-IN-1
Cat. No.:
HY-18607
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SGK1-IN-1

Cat. No.: HY-18607