1. Metabolic Enzyme/Protease
  2. SGK
  3. SGK1-IN-1

SGK1-IN-1 

Cat. No.: HY-18607 Purity: 98.76%
Handling Instructions

SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.

For research use only. We do not sell to patients.

SGK1-IN-1 Chemical Structure

SGK1-IN-1 Chemical Structure

CAS No. : 1279829-87-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 322 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.

IC50 & Target

IC50: 1 nM (SGK-1)[1][2].

In Vitro

SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3, with IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively. SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM[2].

Molecular Weight

418.83

Formula

C₁₇H₁₂ClFN₆O₂S

CAS No.

1279829-87-6

SMILES

O=S(C1=C(F)C=CC(Cl)=C1)(NC2=CC=C(C3=NC(NN=C4N)=C4N=C3)C=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

SGK1-IN-1SGKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseInhibitorinhibitorinhibit

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Product Name:
SGK1-IN-1
Cat. No.:
HY-18607
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