1. PROTAC
    Metabolic Enzyme/Protease
  2. PROTAC
    SGK
  3. PROTAC SGK3 degrader-1

PROTAC SGK3 degrader-1 (Synonyms: SGK3-PROTAC1)

Cat. No.: HY-125878 Purity: 99.32%
Handling Instructions

PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate).

For research use only. We do not sell to patients.

PROTAC SGK3 degrader-1 Chemical Structure

PROTAC SGK3 degrader-1 Chemical Structure

CAS No. : 2381320-35-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 2865 In-stock
Estimated Time of Arrival: December 31
1 mg USD 695 In-stock
Estimated Time of Arrival: December 31
5 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate)[1].

Molecular Weight

1157.38

Formula

C₅₇H₇₃FN₁₀O₁₁S₂

CAS No.

2381320-35-8

SMILES

FC1=C(C=C(C=C1)C)S(=O)(NC2=CC=C(C=C2)C3=NC4=C(C(OC[[email protected]]5CN(CCO5)CCCCCCOCCOCCOCC(N[[email protected]](C(N6[[email protected]@H](C[[email protected]](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=N3)C=NN4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (86.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8640 mL 4.3201 mL 8.6402 mL
5 mM 0.1728 mL 0.8640 mL 1.7280 mL
10 mM 0.0864 mL 0.4320 mL 0.8640 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.16 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.32%

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Keywords:

PROTAC SGK3 degrader-1SGK3-PROTAC1PROTACSGKProteolysis-targeting chimeraSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseInhibitorinhibitorinhibit

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Product Name:
PROTAC SGK3 degrader-1
Cat. No.:
HY-125878
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