1. PROTAC
    Metabolic Enzyme/Protease
  2. PROTAC
    SGK
  3. PROTAC SGK3 degrader-1

PROTAC SGK3 degrader-1 (Synonyms: SGK3-PROTAC1)

Cat. No.: HY-125878
Handling Instructions

PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1( an SGK3 substrate).

For research use only. We do not sell to patients.

PROTAC SGK3 degrader-1 Chemical Structure

PROTAC SGK3 degrader-1 Chemical Structure

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Description

PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1( an SGK3 substrate)[1].

Molecular Weight

1157.38

Formula

C₅₇H₇₃FN₁₀O₁₁S₂

SMILES

FC1=C(C=C(C=C1)C)S(=O)(NC2=CC=C(C=C2)C3=NC4=C(C(OC[[email protected]]5CN(CCO5)CCCCCCOCCOCCOCC(N[[email protected]](C(N6[[email protected]@H](C[[email protected]](C6)O)C(NCC7=CC=C(C=C7)C8=C(N=CS8)C)=O)=O)C(C)(C)C)=O)=N3)C([H])=NN4)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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PROTAC SGK3 degrader-1
Cat. No.:
HY-125878
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