O-Phospho-D-serine
O-Phospho-D-serine (D-SOP) is the D-configurational enantiomer of O-Phospho-L-serine (HY-15129). O-Phospho-D-serine inhibits L-[3H]glutamate binding to APB-sensitive sites in rat brain synaptic plasma membranes, with a Ki of 303 μM. Compared with the L-configurational form, D-SOP does not significantly activate the tested mGluR at 1 mM, and it is mainly used in studies related to the stereoselectivity of phosphatidylserine and mGluR ligands.
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- No. CAS: 73913-63-0
- Fòrmula: C3H8NO6P
- Peso molecular:185.07
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
O-Phospho-D-serine (10-80 mM; 5 min) inhibits the binding of coagulation factor VIII to platelet-derived microparticles, with an inhibition rate of 50% at approximately 80 mM, and its potency is weaker than that of O-Phospho-L-serine[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 73913-63-0
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Peso molecular 185.07
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Fòrmula C3H8NO6P
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SMILES
C([C@H](C(O)=O)N)OP(=O)(O)O
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Synonyms
D-Serine O-phosphate; D-SOP
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Gilbert GE, et al. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine. Biochemistry. 1993 Sep 21;32(37):9577-85. [Content Brief]
[2]. Amori L, et al. Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. Bioorganic & medicinal chemistry letters. 2000 Jul 03;10(13):1447-50. [Content Brief]
[3]. Kang HJ, et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. The Journal of biological chemistry. 2014 Oct 24;289(43):29961-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
O-Phospho-D-serine Related Classifications
HY-15129A Related Classifications
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