O-Phospho-D-serine
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- No. CAS: 73913-63-0
- Fòrmula: C3H8NO6P
- Peso molecular:185.07
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
D-Phospho-D-serine (40-100 mM; 10 min) weakly inhibits factor VIII binding to phosphatidylserine-containing liposphere membranes, with IC50 occurring at approximately 100 mM, which is 5-fold less effective than O-phospho-L-serine[1].
D-Phospho-D-serine (10-80 mM; 5 min) inhibits factor VIII binding to platelet-derived microparticles with 50% inhibition at approximately 80 mM, which is 4-fold less effective than O-phospho-L-serine[1].
D-Phospho-D-serine (1 mM; single incubation for calcium response measurement) does not activate mGluR1, mGluR2, mGluR4, mGluR6, or mGluR7 in transiently transfected HEK-293 cells when tested at 1 mM in a calcium mobilization assay[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 73913-63-0
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Peso molecular 185.07
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Fòrmula C3H8NO6P
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SMILES
C([C@H](C(O)=O)N)OP(=O)(O)O
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Synonyms
D-Serine O-phosphate; D-SOP
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Gilbert GE, et al. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine. Biochemistry. 1993 Sep 21;32(37):9577-85. [Content Brief]
[2]. Amori L, et al. Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. Bioorganic & medicinal chemistry letters. 2000 Jul 03;10(13):1447-50. [Content Brief]
[3]. Kang HJ, et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. The Journal of biological chemistry. 2014 Oct 24;289(43):29961-74. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
O-Phospho-D-serine Related Classifications
HY-15129A Related Classifications
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