73913-63-0
Chemical Structure
O-Phospho-D-serine
Synonym(s): D-Serine O-phosphate; D-SOP
- CAS No.: 73913-63-0
- Formula:C3H8NO6P
- Molecular Weight:185.07
IUPAC Name: O-phosphono-D-serine
InChIKey: BZQFBWGGLXLEPQ-UWTATZPHSA-N
SMILES: C([C@H](C(O)=O)N)OP(=O)(O)O
Biological Activity:
O-Phospho-D-serine (D-SOP) is the D-configurational enantiomer of O-Phospho-L-serine (HY-15129). O-Phospho-D-serine inhibits L-[3H]glutamate binding to APB-sensitive sites in rat brain synaptic plasma membranes, with a Ki of 303 μM. Compared with the L-configurational form, D-SOP does not significantly activate the tested mGluR at 1 mM, and it is mainly used in studies related to the stereoselectivity of phosphatidylserine and mGluR ligands[1][2][3].
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O-Phospho-D-serine | O-Phospho-D-serine (D-SOP) is the D-configurational enantiomer of O-Phospho-L-serine (HY-15129). O-Phospho-D-serine inhibits L-[3H]glutamate binding to APB-sensitive sites in rat brain synaptic plasma membranes, with a Ki of 303 μM. Compared with the L-configurational form, D-SOP does not significantly activate the tested mGluR at 1 mM, and it is mainly used in studies related to the stereoselectivity of phosphatidylserine and mGluR ligands. |
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References
- [1]. Gilbert GE, et al. Specific membrane binding of factor VIII is mediated by O-phospho-L-serine, a moiety of phosphatidylserine. Biochemistry. 1993 Sep 21;32(37):9577-85. [Content Brief]
- [2]. Amori L, et al. Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III. Bioorganic & medicinal chemistry letters. 2000 Jul 03;10(13):1447-50. [Content Brief]
- [3]. Kang HJ, et al. Selectivity and evolutionary divergence of metabotropic glutamate receptors for endogenous ligands and G proteins coupled to phospholipase C or TRP channels. The Journal of biological chemistry. 2014 Oct 24;289(43):29961-74. [Content Brief]
