1. GPCR/G Protein Neuronal Signaling Apoptosis
  2. mGluR Apoptosis
  3. Fenobam

Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction.

For research use only. We do not sell to patients.

Fenobam Chemical Structure

Fenobam Chemical Structure

CAS No. : 57653-26-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
USD 179 In-stock
Solution
10 mM * 1 mL in DMSO USD 179 In-stock
Solid
1 mg USD 61 In-stock
5 mg USD 130 In-stock
10 mg USD 210 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Fenobam is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam has anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells. Fenobam can be used for research on neurological diseases, cancer and drug addiction[1][2][3].

IC50 & Target[1]

mGluR5

84 nM (IC50)

rat mGluR5

54 nM (Kd)

human mGluR5

31 nM (Kd)

In Vitro

Fenobam (300 μM; 72 h) significantly inhibits proliferation and induces apoptosis in LM7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[2]

Cell Line: LM7 cells
Concentration: 300 μM
Incubation Time: 72 h
Result: Significantly reduced total number of cells, proliferating cells, and induced apoptosis.
In Vivo

Fenobam (30-60 mg/kg; p.o.; 3 times a week) significantly inhibits self-administration behavior in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Long-Evans rats (250-300 g)[3].
Dosage: 30-60 mg/kg
Administration: Oral administration; 3 times a week.
Result: Inhibited self-administration.
Clinical Trial
Molecular Weight

266.68

Formula

C11H11ClN4O2

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (374.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7498 mL 18.7491 mL 37.4981 mL
5 mM 0.7500 mL 3.7498 mL 7.4996 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.91%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7498 mL 18.7491 mL 37.4981 mL 93.7453 mL
5 mM 0.7500 mL 3.7498 mL 7.4996 mL 18.7491 mL
10 mM 0.3750 mL 1.8749 mL 3.7498 mL 9.3745 mL
15 mM 0.2500 mL 1.2499 mL 2.4999 mL 6.2497 mL
20 mM 0.1875 mL 0.9375 mL 1.8749 mL 4.6873 mL
25 mM 0.1500 mL 0.7500 mL 1.4999 mL 3.7498 mL
30 mM 0.1250 mL 0.6250 mL 1.2499 mL 3.1248 mL
40 mM 0.0937 mL 0.4687 mL 0.9375 mL 2.3436 mL
50 mM 0.0750 mL 0.3750 mL 0.7500 mL 1.8749 mL
60 mM 0.0625 mL 0.3125 mL 0.6250 mL 1.5624 mL
80 mM 0.0469 mL 0.2344 mL 0.4687 mL 1.1718 mL
100 mM 0.0375 mL 0.1875 mL 0.3750 mL 0.9375 mL
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Fenobam Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Fenobam
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