1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. Fenobam

Fenobam 

Cat. No.: HY-101478 Purity: >99.0%
Handling Instructions

Fenobam is a selective, orally active, and brain-penetrant mGluR5 antagonist acting at an allosteric modulatory site (Kds of 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity.

For research use only. We do not sell to patients.

Fenobam Chemical Structure

Fenobam Chemical Structure

CAS No. : 57653-26-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 205 In-stock
Estimated Time of Arrival: December 31
1 mg USD 120 In-stock
Estimated Time of Arrival: December 31
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Fenobam is a selective, orally active, and brain-penetrant mGluR5 antagonist acting at an allosteric modulatory site (Kds of 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). Fenobam displays inverse agonist activity which blocks the mGlu5 receptor basal activity with an IC50 of 84 nM. Fenobam exerts anxiolytic activity[1][2].

IC50 & Target[1]

rat mGluR5

54 nM (Kd)

human mGluR5

31 nM (Kd)

In Vivo

Fenobam sulfate (30-60 mg/kg; p.o.) significantly inhibited cocaine self-administration [3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Long-Evans rats (250-300 g)[3]
Dosage: 30-60 mg/kg
Administration: P.o.
Result: Inhibited cocaine self-administration
Clinical Trial
Molecular Weight

266.68

Formula

C₁₁H₁₁ClN₄O₂

CAS No.

57653-26-6

SMILES

O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: >99.0%

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Keywords:

FenobammGluRMetabotropic glutamate receptorsbrain-penetrantnonbenzodiazepineanxiolyticcocaineaddictionInhibitorinhibitorinhibit

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Fenobam
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HY-101478
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