2. GPCR/G Protein Neuronal Signaling Apoptosis
  3. mGluR Apoptosis
  4. Fenobam hydrate

Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction.

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Fenobam hydrate Chemical Structure

Fenobam hydrate Chemical Structure

CAS No. : 63540-28-3

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Fenobam hydrate Related Antibodies

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Description

Fenobam hydrate is a selective and orally active mGluR5 antagonist (IC50=84 nM) that can penetrate the blood-brain barrier. Fenobam hydrate shows the Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate has anxiolytic activity, inhibits self-administration behavior in rat, and induces apoptosis in cancer cells. Fenobam hydrate can be used for research on neurological diseases, cancer and drug addiction[1][2][3].

IC50 & Target[1]

mGluR5

84 nM (IC50)

human mGluR5

31 nM (Kd)

rat mGluR5

54 nM (Kd)

In Vitro

Fenobam hydrate (300 μM; 72 h) significantly inhibits proliferation and induces apoptosis in LM7 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fenobam hydrate Related Antibodies

Apoptosis Analysis[2]

Cell Line: LM7 cells
Concentration: 300 μM
Incubation Time: 72 h
Result: Significantly reduced total number of cells, proliferating cells, and induced apoptosis.
In Vivo

Fenobam hydrate (30-60 mg/kg; p.o.; 3 times a week) significantly inhibits self-administration behavior in rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Long-Evans rats (250-300 g)[3].
Dosage: 30-60 mg/kg
Administration: Oral administration; 3 times a week.
Result: Inhibited self-administration.
Molecular Weight

284.70

Formula

C11H13ClN4O3
CAS No.
SMILES

O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fenobam hydrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenobam63540-28-3mGluRApoptosisMetabotropic glutamate receptorsLM7cancerapoptosisanxiolyticproliferationdrug addictionInhibitorinhibitorinhibit

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