851881-60-2
851881-60-2
Chemical Structure
ADX-47273
- CAS No.: 851881-60-2
- Formula:C20H17F2N3O2
- Molecular Weight:369.36
IUPAC Name: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl)piperidin-1-yl)methanone
InChIKey: VXQCCZHCFBHTTD-HNNXBMFYSA-N
SMILES: O=C(C1=CC=C(F)C=C1)N2C[C@@H](C3=NC(C4=CC=C(F)C=C4)=NO3)CCC2
Biological Activity: ADX-47273 is a potent, selective and brain-penetrant mGluR5 positive allosteric modulator (PAM), with an EC50 of 0.17 μM for potentiation of glutamate (50 nM) response. ADX-47273 has antipsychotic and procognitive activities[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ADX-47273 | 98.77% | ADX-47273 is a potent, selective and brain-penetrant mGluR5 positive allosteric modulator (PAM), with an EC50 of 0.17 μM for potentiation of glutamate (50 nM) response. ADX-47273 has antipsychotic and procognitive activities. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-13058B(R)-ADX-47273 -
Similarity Score 0.57
HY-13933120S Proteasome-IN-1 -
Similarity Score 0.54
HY-W237439SEN205A -
Similarity Score 0.54
HY-118256LSN2814617 -
Similarity Score 0.54
HY-118256A(Rac)-LSN2814617 -
Similarity Score 0.51
HY-163698SIRT-IN-4 -
Similarity Score 0.51
HY-167890Flufenoxadiazam -
Similarity Score 0.51
HY-175006AChE-IN-91 -
Similarity Score 0.50
HY-103651OT antagonist 1 demethyl derivative -
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References
- [1]. Liu F, et al. ADX47273 [S-(4-fluoro-phenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}-methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 2008 Dec;327(3):827-39. [Content Brief]
- [2]. Schlumberger C, et, al. Effects of a positive allosteric modulator of mGluR5 ADX47273 on conditioned avoidance response and PCP-induced hyperlocomotion in the rat as models for schizophrenia. Pharmacol Biochem Behav. 2010 Mar;95(1):23-30. [Content Brief]
