SEN205A
SEN205A is a fragment compound that binds to the hydrophobic pocket of human S100B (Kd=0.5-1.0 mM), which is the key region for the interaction of S100B with TRTK-12 and p53, and SEN205A can be displaced from this site by TRTK-12. SEN205A exhibits excellent in vitro ADME properties, including high metabolic stability, chemical stability, and good solubility under physiological pH conditions. SEN205A can serve as a starting fragment for structure-based optimization to develop inhibitors targeting the S100B-p53 protein-protein interaction and investigate the pathogenesis of malignant melanoma.
For research use only. We do not sell to patients.
- CAS No.: 958712-85-1
- Formula: C13H14ClN3O
- Molecular Weight:263.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
SEN205A (800 μM; 5-fold molar excess over monomeric S100B; 0.5-1 equivalents TRTK-12) binds to the p53/TRTK-12 interaction site of human S100B with an estimated Kd of 0.5-1.0 mM, and is fully displaceable from the site by the high-affinity TRTK-12 peptide[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 958712-85-1
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Molecular Weight 263.73
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Formula C13H14ClN3O
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SMILES
ClC=1C=CC(=CC1)C2=NOC(=N2)C3CNCCC3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SEN205A Related Classifications
HY-W237439 Related Classifications
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