SEN205A 

SEN205A is a fragment compound that binds to the hydrophobic pocket of human S100B (K_d=0.5-1.0 mM), which is the key region for the interaction of S100B with TRTK-12 and p53, and SEN205A can be displaced from this site by TRTK-12. SEN205A exhibits excellent in vitro ADME properties, including high metabolic stability, chemical stability, and good solubility under physiological pH conditions. SEN205A can serve as a starting fragment for structure-based optimization to develop inhibitors targeting the S100B-p53 protein-protein interaction and investigate the pathogenesis of malignant melanoma^[1].

SEN205A (800 μM; 5-fold molar excess over monomeric S100B; 0.5-1 equivalents TRTK-12) binds to the p53/TRTK-12 interaction site of human S100B with an estimated K_d of 0.5-1.0 mM, and is fully displaceable from the site by the high-affinity TRTK-12 peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

263.73

C₁₃H₁₄ClN₃O

958712-85-1

ClC=1C=CC(=CC1)C2=NOC(=N2)C3CNCCC3

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Agamennone M, et al. Fragmenting the S100B-p53 interaction: combined virtual/biophysical screening approaches to identify ligands. ChemMedChem. 2010;5(3):428-435.  [Content Brief]