1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. Mavoglurant

Mavoglurant (Synonyms: AFQ056)

Cat. No.: HY-15257 Purity: 99.99%
Handling Instructions

Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5.

For research use only. We do not sell to patients.

Mavoglurant Chemical Structure

Mavoglurant Chemical Structure

CAS No. : 543906-09-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 462 In-stock
Estimated Time of Arrival: December 31
5 mg USD 420 In-stock
Estimated Time of Arrival: December 31
10 mg USD 540 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2520 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Mavoglurant:

Top Publications Citing Use of Products
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Description

Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5. IC50 value: 30 nM Target: mGluR5 in vitro: Mavoglurant is a selective non-competitive antagonist which showed efficacy in the treatment of L-dopa induced dyskinesias in Parkinson's disease and Fragile X mental retardation in proof of principle studies. Mavoglurant is selective over the other mGluR subtypes, iGluRs and a panel of 238 CNS relevant receptors, transporter or enzymes. [1] In vivo: Mavoglurant shows an improved pharmacokinetic profile in rat and efficacy in the stress-induced hyperthermia test in mice as compared to the prototypic mGluR5 antagonist MPEP.[1]

Clinical Trial
Molecular Weight

313.39

Formula

C₁₉H₂₃NO₃

CAS No.

543906-09-8

SMILES

CC1=CC(C#C[[email protected]]2(O)CCC[[email protected]]3([H])[[email protected]@]2([H])CCN3C(OC)=O)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (149.97 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1909 mL 15.9546 mL 31.9091 mL
5 mM 0.6382 mL 3.1909 mL 6.3818 mL
10 mM 0.3191 mL 1.5955 mL 3.1909 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.99%

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Keywords:

MavoglurantAFQ056AFQ 056AFQ-056mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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Mavoglurant
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HY-15257
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