1. GPCR/G Protein
  2. mGluR

Mavoglurant (Synonyms: AFQ056)

Cat. No.: HY-15257 Purity: 99.74% ee.: 99.90%
Data Sheet SDS Handling Instructions

Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5.

For research use only. We do not sell to patients.
Mavoglurant Chemical Structure

Mavoglurant Chemical Structure

CAS No. : 543906-09-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO $385 In-stock
5 mg $350 In-stock
10 mg $450 In-stock
50 mg $1500 In-stock
100 mg $2100 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Mavoglurant:

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  • Purity & Documentation

  • References

Description

Mavoglurant is a structurally novel, non-competitive mGlu5 receptor antagonist, has an IC50 of 30 nM in a functional assay with human mGluR5. IC50 value: 30 nM Target: mGluR5 in vitro: Mavoglurant is a selective non-competitive antagonist which showed efficacy in the treatment of L-dopa induced dyskinesias in Parkinson's disease and Fragile X mental retardation in proof of principle studies. Mavoglurant is selective over the other mGluR subtypes, iGluRs and a panel of 238 CNS relevant receptors, transporter or enzymes. [1] In vivo: Mavoglurant shows an improved pharmacokinetic profile in rat and efficacy in the stress-induced hyperthermia test in mice as compared to the prototypic mGluR5 antagonist MPEP.[1]

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References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.1909 mL 15.9546 mL 31.9091 mL
5 mM 0.6382 mL 3.1909 mL 6.3818 mL
10 mM 0.3191 mL 1.5955 mL 3.1909 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

313.39

Formula

C₁₉H₂₃NO₃

CAS No.

543906-09-8

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 47 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Purity: 99.74% ee.: 99.90%

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Product Name:
Mavoglurant
Cat. No.:
HY-15257
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