1. GPCR/G Protein
    Neuronal Signaling
  2. mGluR
  3. Mavoglurant racemate

Mavoglurant racemate (Synonyms: AFQ-056 racemate)

Cat. No.: HY-15257A Purity: 98.88%
Handling Instructions

Mavoglurant racemate (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist.

For research use only. We do not sell to patients.

Mavoglurant racemate Chemical Structure

Mavoglurant racemate Chemical Structure

CAS No. : 1636881-61-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 724 In-stock
Estimated Time of Arrival: December 31
2 mg USD 420 In-stock
Estimated Time of Arrival: December 31
5 mg USD 840 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Mavoglurant racemate:

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Description

Mavoglurant racemate (AFQ-056 racemate) is the racemate of Mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist[1].

IC50 & Target[1]

mGluR5

 

In Vitro

For antagonistic activity, (−)-mavoglurant, the (−)-enantiomer shows IC50 of 0.11 μM and 0.03 μM (Ca2+ and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM[1].

Molecular Weight

313.39

Formula

C₁₉H₂₃NO₃

CAS No.

1636881-61-2

SMILES

O=C(N1CC[[email protected]@]2([H])[[email protected]@](C#CC3=CC=CC(C)=C3)(O)CCC[[email protected]@]12[H])OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (159.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1909 mL 15.9546 mL 31.9091 mL
5 mM 0.6382 mL 3.1909 mL 6.3818 mL
10 mM 0.3191 mL 1.5955 mL 3.1909 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (5.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (5.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (5.33 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MavoglurantAFQ-056AFQ056AFQ 056mGluRMetabotropic glutamate receptorsInhibitorinhibitorinhibit

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Mavoglurant racemate
Cat. No.:
HY-15257A
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