Impact of amyloid-β peptide (1-42) on voltage-gated ion currents in molluscan neurons

  • Bull Exp Biol Med. 2011 Oct;151(6):671-4. doi: 10.1007/s10517-011-1412-y.
E I Solntseva  1 ,  J V Bukanova ,  E V Marchenko ,  V G Skrebitsky
Affiliations
  • 1. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. [email protected]
PMID: 22485204 DOI: 10.1007/s10517-011-1412-y
Abstract

Different types of voltage-gated ion currents were recorded in isolated neurons of snail Helix pomatia using the two-microelectrode voltage-clamp technique. Application of Amyloid-β peptide (1-42, 1-10 μM) in the bathing solution did not change delayed rectifier K(+)-current and leakage current, but enhanced inactivation of CA(2+)-current and blocked CA(2+)-dependent K(+)-current.

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