Pyrrole: An insight into recent pharmacological advances with structure activity relationship

  • Eur J Med Chem. 2018 Sep 5:157:527-561. doi: 10.1016/j.ejmech.2018.08.002.
Shujauddin Ahmad  1 ,  Ozair Alam  2 ,  Mohd Javed Naim  1 ,  Mohammad Shaquiquzzaman  1 ,  M Mumtaz Alam  1 ,  Muzaffar Iqbal  3
Affiliations
  • 1. Medicinal Chemistry and Molecular Modelling Lab, Dept. of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, 62, India.
  • 2. Medicinal Chemistry and Molecular Modelling Lab, Dept. of Pharmaceutical Chemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, Hamdard Nagar, New Delhi, 62, India. Electronic address: [email protected].
  • 3. Dept. of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
PMID: 30119011 DOI: 10.1016/j.ejmech.2018.08.002
Abstract

Pyrrole is a heterocyclic ring template with multiple pharmacophores that provides a way for the generation of library of enormous lead molecules. Owing to its vast pharmacological profile, pyrrole and its analogues have drawn much attention of the researchers/chemists round the globe to be explored exhaustively for the benefit of mankind. This review focusses on recent advancements; pertaining to pyrrole scaffold, discussing various aspects of structure activity relationship and its bioactivities.

Keywords
Anticancer; Antimicrobial; Pyrrole; Structure activity relationship.