Stabilization of microtubules by Combretastatin D derivatives

  • Bioorg Med Chem Lett. 1999 Oct 18;9(20):2927-8. doi: 10.1016/s0960-894x(99)00503-x.
E A Couladouros  1 ,  T Li ,  V I Moutsos ,  E N Pitsinos ,  I C Soufli
Affiliations
  • 1. Chemistry Laboratories, Agricultural University of Athens, Greece. [email protected]
PMID: 10571149 DOI: 10.1016/s0960-894x(99)00503-x
Abstract

The effect of five derivatives of Combretastatin D on tubulin polymerization was investigated. All of them were found to stabilize microtubules to various degrees. The derivatives bearing polar substituents were found to be the most active.