New phenstatin-fatty acid conjugates: synthesis and evaluation

  • Bioorg Med Chem Lett. 2013 Sep 15;23(18):5119-22. doi: 10.1016/j.bmcl.2013.07.025.
Jinhui Chen  1 ,  David P Brown ,  Yi-Jun Wang ,  Zhe-Sheng Chen
Affiliations
  • 1. Department of Chemistry, St. John's University, Jamaica, NY 11439, USA.
PMID: 23932339 DOI: 10.1016/j.bmcl.2013.07.025
Abstract

New phenstatin-fatty acid conjugates have been synthesized and tested against the KB-3-1, H460, MCF-7 and HEK293 cell lines, with an increase in anti-proliferative activity being observed at the micro-molar level paralleling an increase in un-saturation in the fatty acid component.

Keywords
Cancer chemotherapy; Conjugates; Drug resistance reversal; Fatty acids; Microtubule-binding drugs.