1. Immunology/Inflammation
  2. NOD-like Receptor (NLR)
  3. GSK717

GSK717 

Cat. No.: HY-136555
Handling Instructions

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.

For research use only. We do not sell to patients.

GSK717 Chemical Structure

GSK717 Chemical Structure

CAS No. : 1595278-21-9

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Description

GSK717 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor. GSK717 inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling, with an IC50 of 400 nM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells[1].

In Vitro

GSK717 blocks synergy between NOD2 and TLR2. GSK717 does not affect NOD1, TNFR1 and TLR2-mediated responses. GSK717 (5 μM) inhibits the release of IL-8, IL-6, TNFα and IL-1β in primary human monocytes stimulated with MDP[1].

Molecular Weight

452.55

Formula

C₂₈H₂₈N₄O₂

CAS No.

1595278-21-9

SMILES

O=C(NC1=CC=C2C(CCC2)=C1)CN3C4=CC=CC=C4N=C3CCN(C)C(C5=CC=CC=C5)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

GSK717GSK 717GSK-717NOD-like Receptor (NLR)pro-inflammatorycytokinesimmuneresponsesMDP-stimulatedNOD2-TLR2synergyInhibitorinhibitorinhibit

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