2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NT-0796

NT-0796 is a selective and CNS-penetrant NLRP3 inflammasome inhibitor with an IC50 of 0.32 nM in PBMC assay. NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795, the carboxylic acid active species. NT-0796 has the potential for neuroinflammatory diseases research.

For research use only. We do not sell to patients.

NT-0796 Chemical Structure

NT-0796 Chemical Structure

CAS No. : 2272917-13-0

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Description

NT-0796 is a selective and CNS-penetrant NLRP3 inflammasome inhibitor with an IC50 of 0.32 nM in PBMC assay. NT-0796 is an isopropyl ester that undergoes intracellular conversion to NDT-19795, the carboxylic acid active species. NT-0796 has the potential for neuroinflammatory diseases research[1].

Molecular Weight

409.48

Formula

C23H27N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)OC([C@H](OC(NC1=C2C(CCC2)=CC3=C1CCC3)=O)CC4=NC=CC=N4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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NT-0796 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NT-07962272917-13-0NT0796NT 0796NOD-like Receptor (NLR)CNSinflammasomePBMCisopropyl esterNDT-19795neuroinflammatory diseasesInhibitorinhibitorinhibit

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