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Cat. No.: HY-179294

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POI ligand-2

POI ligand-2 is a ligand for GPX4 protein. POI ligand-2 can be used to synthesize PROTAC, such as PROTAC GPX4 degrader-5 (HY-178925).

For research use only. We do not sell to patients.

CAS No.: 3119292-09-7
Formula: C₂₅H₂₁ClN₂O₅S
Molecular Weight:496.96

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

POI ligand-2 Chemical Structure

CAS No.: 3119292-09-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

POI ligand-2 is a ligand for GPX4 protein. POI ligand-2 can be used to synthesize PROTAC, such as PROTAC GPX4 degrader-5 (HY-178925)^[1].

IC₅₀ & Target

^[1]

GPX4

All Glutathione Peroxidase Isoforms :

GPX1
GPX4

Chemical Information

CAS No. 3119292-09-7
Molecular Weight 496.96
Formula C₂₅H₂₁ClN₂O₅S
SMILES

ClC(C=C1N(C(C#C)=O)C(C(NCCC2=CC=CC=C2)=O)C3=CC=CS3)=C(C=C1)OCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ning Y, et al. Design, synthesis, and biological evaluation of ML162-based glutathione peroxidase 4 (GPX4) degraders with hydrophobic tags. Eur J Med Chem. 2026 Jan 5;301:118269. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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POI ligand-2

All Glutathione Peroxidase Isoforms

Biological Activity

Description

IC50 & Target

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

POI ligand-2 Related Classifications

HY-179294 Related Classifications

Bioz

Keywords

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