PROTAC GPX4 degrader-5
Based on 1 Customer Validation
PROTAC GPX4 degrader-5 (compound N15) is an efficient and highly selective PROTAC GPX4 degrader (DC50 = 28 nM). PROTAC GPX4 degrader-5 can induce ferroptosis and has low toxicity to normal cells. PROTAC GPX4 degrader-5 can significantly increase ROS. PROTAC GPX4 degrader-5 exerts anti proliferative effects on various tumor cells. PROTAC GPX4 degrader-5 is commonly used in cancer research.
(Pink: GPX4 ligand (HY-179294); Blue: Others ligand (HY-N2427); Black: linker (HY-W047688)).
For research use only. We do not sell to patients.
- Purity: 95.0%
- CAS No.: 3119292-91-7
- Formula: C47H59ClN4O5S
- Molecular Weight:827.51
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Immunology/Inflammation Compound Library
HY-L007
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Metabolism/Protease Compound Library
HY-L012
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Antioxidant Compound Library
HY-L037
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Oxygen Sensing Compound Library
HY-L045
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Ferroptosis Compound Library
HY-L051
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Anti-Cancer Metabolism Compound Library
HY-L083
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Metabolic Enzyme Compound Library
HY-L146
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PROTAC Library
HY-L151
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Highly Selective Activators Library
HY-L159
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Cell Death Library
HY-L162
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Radioprotector Library
HY-L178
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MCE Bioactive Compound Library
HY-L001V
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Protein Kinase Compound Library
HY-L196
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
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Alkyne Compound Library
HY-L258
All PROTACs Isoforms
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Biological Activity
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GPX4 28 nM (DC50) |
Chemical Information
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CAS No. 3119292-91-7
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Appearance Solid
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Molecular Weight 827.51
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Formula C47H59ClN4O5S
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Color White to off-white
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SMILES
O=C(NCCC1=CC=CC=C1)C(C2=CC=CS2)N(C3=CC=C(C(Cl)=C3)OCC(NCCCCCCCCCCNC(CC4(C[C@@H]5C6)C[C@H](C5)C[C@H]6C4)=O)=O)C(C#C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (120.84 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (3.02 mM); Suspended solution; Need ultrasonic
This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (269 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2084 mL | 6.0422 mL | 12.0844 mL | 30.2111 mL |
| 5 mM | 0.2417 mL | 1.2084 mL | 2.4169 mL | 6.0422 mL | |
| 10 mM | 0.1208 mL | 0.6042 mL | 1.2084 mL | 3.0211 mL | |
| 15 mM | 0.0806 mL | 0.4028 mL | 0.8056 mL | 2.0141 mL | |
| 20 mM | 0.0604 mL | 0.3021 mL | 0.6042 mL | 1.5106 mL | |
| 25 mM | 0.0483 mL | 0.2417 mL | 0.4834 mL | 1.2084 mL | |
| 30 mM | 0.0403 mL | 0.2014 mL | 0.4028 mL | 1.0070 mL | |
| 40 mM | 0.0302 mL | 0.1511 mL | 0.3021 mL | 0.7553 mL | |
| 50 mM | 0.0242 mL | 0.1208 mL | 0.2417 mL | 0.6042 mL | |
| 60 mM | 0.0201 mL | 0.1007 mL | 0.2014 mL | 0.5035 mL | |
| 80 mM | 0.0151 mL | 0.0755 mL | 0.1511 mL | 0.3776 mL | |
| 100 mM | 0.0121 mL | 0.0604 mL | 0.1208 mL | 0.3021 mL |
PROTAC GPX4 degrader-5 Related Classifications
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