2. Apoptosis
  3. Apoptosis Ferroptosis
  4. GIC-20

GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma.

For research use only. We do not sell to patients.

GIC-20 Chemical Structure

GIC-20 Chemical Structure

CAS No. : 2942242-60-4

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

GIC-20 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GIC-20 is a dual inducer for apoptosis and ferroptosis. GIC-20 exhibits antitumor efficacy against fibrosarcoma[1].

In Vitro

GIC-20 (1 μM, 48 h) inhibits proliferation and migration of HT1080 fibrosarcoma cells, exhibits cytotoxicity with IC50 of 1.6 μM[1].
GIC-20 (0.5-4 μM, 24 h) induces ferroptosis by inducing intracellular lipid peroxide and ROS accumulation, or by degradation of GPX4[1].
GIC-20 (0-1 μM, 24 h) inhibits cell viability of drug-resistant MIA-PaCa-2-AMG510R cells, enhances the sensitivity of MIA-PaCa-2-AMG510R cells to AMG510[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GIC-20 Related Antibodies

Western Blot Analysis[1]

Cell Line: HT1080
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Inhibited expression of GPX4 and Bcl-2, promoted expression of Bax.

Apoptosis Analysis[1]

Cell Line: HT1080
Concentration: 0-4 μM
Incubation Time: 24 h
Result: Induced apoptosis in a dose-dependent manner.
In Vivo

GIC-20 (20-40 mg/kg, i.p., once daily for 19 days) exhibits antitumor efficacy in HT1080 xenograft BALB/c mice, without significant toxicity in major organs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT1080 xenograft BALB/c mice[1]
Dosage: 20-40 mg/kg
Administration: i.p., once a day for 19 days
Result: Inhibited tumor growth, with a TGI of 63% at 40 mg/kg.
Maintained a complete morphology without obvious cellular inflammatory, oedema, or necrosis in major organs.
Molecular Weight

697.24

Formula

C38H37ClN4O5S
CAS No.
SMILES

O=C1C=C(NCCCCCC(NC2=CC=C(N(C(C(NCCC3=CC=CC=C3)=O)C4=CC=CS4)C(CCl)=O)C=C2)=O)C(C5=CC=CC=C51)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GIC-20 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GIC-202942242-60-4GIC20GIC 20ApoptosisFerroptosisHT1080fibrosarcoma MIA-PaCa-2-AMG510RInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GIC-20
Cat. No.:
HY-162449
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.