Cat. No.: HY-120912

Gingerenone A

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Gingerenone A is an Nrf2-Gpx4 activator that can induce Ferroptosis in liver damage with oral activity. Gingerenone A has anti-inflammatory, anti-diabetic, anti-tumor, and pro-aging effects in mice.

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Pureté: 99.95%
CAS No.: 128700-97-0
Formule: C₂₁H₂₄O₅
Masse moléculaire:356.41

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Gingerenone A Chemical Structure

CAS No.: 128700-97-0

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Cell Proliferation/Viability AssayELISAIFCell Migration/Invasion AssayWBHistological Imaging/Staining

Cell Proliferation/Viability Assay
ELISA
IF
Cell Migration/Invasion Assay
WB
Histological Imaging/Staining

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (2)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

GPX4

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase :

GPX1
GPX4

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	24 μM Compound: 40	Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay Cytotoxicity against HEK293 cells after 16 hrs by alamar blue assay	[PMID: 20004045]

In Vitro

Gingerenone A (2.5-40 μM, 5 h) overcomes insulin resistance and increases glucose uptake in 3T3-L1 cells by inhibiting S6K1 activity^[1].
Gingerenone A (40 μM, 6 days) inhibits lipogenesis and lipid accumulation in 3T3-L1 cells^[2].
Gingerenone A (0-40 μM, 6 days) suppresses the proliferation and hypertrophy of 3T3-L1 cells, regulating the expression or phosphorylation levels of proteins related to lipogenesis and fatty acid metabolism^[2].
Gingerenone A promotes anti-proliferation and senescence in breast cancer cells induced by oxidative stress^[3].
Gingerenone A with an IC₅₀ values for breast cancer cells (SKBR3, MCF-7 and MDA-MB-231) is 50.41, 42.67, 56.29 µM in a 48-hour TP experiment ^[3].
Gingerenone A (80 μM, 48 h) causes a delay in the G2/M phase of MCF7 and MDA-MB-231 cells^[3].
Gingerenone A (80 μM, 1.5-3 h) induces an increase in ROS levels in MCF7 and MDA-MB-231 cells^[3].
Gingerenone A (0-80 μM, 48 h) induces senescence in MCF7 and MDA-MB-231 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

3T3-L1
Concentration:

0, 2.5, 5, 10, 20, 40 μM
Incubation Time:

5 h
Result:

Increased AKT^S473 and S6K1^T389, decreased phosphorylation of S6^S235/236 and insulin receptor substrate 1 (IRS-1) S1101, and increased binding of IRS-1 to PI3K.

Immunofluorescence^[2]

Cell Line:

3T3-L1
Concentration:

40 μM
Incubation Time:

6 days
Result:

Inhibits cellular adipogenesis and lipid accumulation.

Western Blot Analysis^[2]

Cell Line:

3T3-L1
Concentration:

0, 10, 20, 40 μM
Incubation Time:

6 days
Result:

Inhibited PPAR-γ, C/EBP-α, and FAS protein levels, decreased SREBP-1 and FAS (lipogenesis markers) protein expression levels, and increased PGC-1α and CPT-1 (fatty acid oxidation markers) protein expression levels.

Cell Viability Assay^[3]

Cell Line:

MCF7, SKBR3, M10, MDA-MB-231
Concentration:

0, 20, 40, 60, 80μM
Incubation Time:

48 h
Result:

Inhibited tumor cell proliferation with little effect on normal cells.

Cell Cycle Analysis^[3]

Cell Line:

MCF7, MDA-MB-231
Concentration:

80 μM
Incubation Time:

48 h
Result:

Increased subG1, moderately decreased G1, and increased G2/M populations.

Real Time qPCR^[3]

Cell Line:

MCF-7, MDA-MB-231
Concentration:

0, 40, 80 μM
Incubation Time:

5 h
Result:

Upregulated the expression of aging-related genes EDN1, ANKRD1, CDKN1A, SERPINE and TAGLN.

In Vivo

Gingerenone A (10-50 mg/kg, orally, once a day, 15 weeks) reduces the increase in fat mass induced by a high-fat diet in mice by decreasing the size of fat cells, thereby inhibiting obesity and inflammation in adipose tissue^[2].
Gingerenone A (5-20 mg/kg, orally, once a day, 7 days) can alleviate ferroptosis in the SLI of DSS-induced colitis mice, and its protective effect is associated with the activation of the Nrf2-Gpx4 signaling pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

HFD mice^[2]
Dosage:

10, 50 mg/kg; daily; 15 weeks
Administration:

Oral
Result:

Reduced fat gain without significantly affecting caloric intake, reduced visceral fat mass, and made fat cells smaller.

Animal Model:

Mice induced by DSS^[6]
Dosage:

5, 20 mg/kg; daily; 7 days
Administration:

Oral
Result:

Alleviated DSS-induced liver pathological damage, liver parameters and cytokine levels, increased antioxidant enzyme activities, alleviated ferroptosis, upregulated GPX4 expression, and activated Nrf2.

Chemical Information

CAS No. 128700-97-0
Appearance Solid
Masse moléculaire 356.41
Formule C₂₁H₂₄O₅
Color Light yellow to yellow
SMILES

O=C(/C=C/CCC1=CC=C(O)C(OC)=C1)CCC2=CC=C(O)C(OC)=C2
Structure Classification
- Phenols
- Polyphenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (2)

All Cell Proliferation/Viability AssayELISAIFCell Migration/Invasion AssayWBHistological Imaging/Staining

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Journal Impact Factor

Nat Aging

Comparative analysis of senolytic drugs reveals mitochondrial determinants of efficacy and resistance. [Abstract]

2026 Feb;6(2):316-328. PMID: 41611832
J Ethnopharmacol

Gingerenone A ameliorates airway inflammation and remodeling in asthma by modulating the TLR4/MyD88/NF-κB pathway. [Abstract]

2025 Sep 30:120656. PMID: 41038330

Gingerenone A purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Sep 30:120656. [Abstract]

The vitality of MLE-12 cells following 24 h of treatment with varying concentrations of Gingerenone A (GA) (5-80 μM). The results indicated that GA concentrations below 40 μM had no cytotoxic effects on MLE-12 cells.

Gingerenone A purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Sep 30:120656. [Abstract]

Gingerenone A (GA) (5-80 μM) treatment significantly decreased the HDM-induced secretion of IL-25 and IL-1β by epithelial cells.

Gingerenone A purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Sep 30:120656. [Abstract]

Representative immunofluorescence images showing p65 nuclear translocation in MLE-12 cells after treatment with different concentrations of HDM and/or Gingerenone A (GA) (5-20 μM) (scale bar = 50 μm), along with quantitative analysis of the nuclear/cytoplasmic fluorescence intensity ratio. The results showed that GA treatment reduced HDM-induced NF-κB nuclear translocation. Quantitative analysis of nuclear/cytoplasmic fluorescence intensity ratios reveals significantly lower NF-κB nuclear accumulation in the GA group (10-20 μM) versus the HDM group (P < 0.05).

Gingerenone A purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Sep 30:120656. [Abstract]

Representative images (scale bar = 100 μm) of the migration assay of MLE-12 cells under Gingerenone A (GA) and HDM stimulation, along with the migration cell ratio relative to the control group (n = 3). The results showed that 48-h of HDM stimulation increased MLE-12 cell migration. However, after GA treatment at 5, 10, and 20 μM, migration rates significantly decreased. These data indicate that GA substantially inhibits HDM-induced increases in airway epithelial cell migration.

Gingerenone A purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Sep 30:120656. [Abstract]

Western blot analysis for E-cadherin, N-cadherin and vimentin in MLE-12 cells under Gingerenone A (GA) (5-20 μM) and HDM stimulation (n = 3). The results revealed that treatment with HDM caused a significant reduction in E-cadherin (epithelial marker) and simultaneous elevation of N-cadherin and vimentin (mesenchymal markers). In contrast, GA treatment effectively counteracted these changes in protein levels.

Gingerenone A purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2025 Sep 30:120656. [Abstract]

Gingerenone A (GA) (10-20 mg/kg; i.p.; once daily for 7 days) markedly alleviated extensive inflammatory cell infiltration in the pulmonary vasculature and alveoli of asthmatic mice.

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (280.58 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.8058 mL

14.0288 mL

28.0576 mL

5 mM

0.5612 mL

2.8058 mL

5.6115 mL

10 mM

0.2806 mL

1.4029 mL

2.8058 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: 2.5 mg/mL (7.01 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (7.01 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: 2.5 mg/mL (7.01 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (280 KB)
SDS (537 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Junhong Chen, et al. Gingerenone A Sensitizes the Insulin Receptor and Increases Glucose Uptake by Inhibiting the Activity of p70 S6 Kinase. Mol Nutr Food Res.2018 Dec;62(23):e1800709. [Content Brief]

[2]. Sujin Suk, et al. Gingerenone A, a polyphenol present in ginger, suppresses obesity and adipose tissue inflammation in high-fat diet-fed mice. Mol Nutr Food Res. 2017 Oct;61(10):10.1002/mnfr.201700139. [Content Brief]

[3]. Yu TJ, et al. Gingerenone A Induces Antiproliferation and Senescence of Breast Cancer Cells. Antioxidants (Basel). 2022 Mar 19;11(3):587. [Content Brief]

[4]. Chen Y, et al. Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway. J Agric Food Chem. 2022 Oct 5;70(39):12525-12534. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.8058 mL	14.0288 mL	28.0576 mL	70.1439 mL
	5 mM	0.5612 mL	2.8058 mL	5.6115 mL	14.0288 mL
	10 mM	0.2806 mL	1.4029 mL	2.8058 mL	7.0144 mL
	15 mM	0.1871 mL	0.9353 mL	1.8705 mL	4.6763 mL
	20 mM	0.1403 mL	0.7014 mL	1.4029 mL	3.5072 mL
	25 mM	0.1122 mL	0.5612 mL	1.1223 mL	2.8058 mL
	30 mM	0.0935 mL	0.4676 mL	0.9353 mL	2.3381 mL
	40 mM	0.0701 mL	0.3507 mL	0.7014 mL	1.7536 mL
	50 mM	0.0561 mL	0.2806 mL	0.5612 mL	1.4029 mL
	60 mM	0.0468 mL	0.2338 mL	0.4676 mL	1.1691 mL
	80 mM	0.0351 mL	0.1754 mL	0.3507 mL	0.8768 mL
	100 mM	0.0281 mL	0.1403 mL	0.2806 mL	0.7014 mL

Keywords

Gingerenone A

2 Cited Publications

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Gingerenone A

Immunology/Inflammation Compound Library

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Publications Citing Use of MedChemExpress (MCE) Gingerenone A

Voir tous les produits spécifiques à Isoform Glutathione Peroxidase

Activité biologique

Chemical Information

Publications (2)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Gingerenone A Related Classifications

HY-120912 Related Classifications