1161002-05-6
1161002-05-6
Chemical Structure
G15
- CAS No.: 1161002-05-6
- Formula:C19H16BrNO2
- Molecular Weight:370.24
IUPAC Name: (3aS,4R,9bR)-4-(6-bromobenzo[d][1,3]dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
InChIKey: YOLTZIVRJAPVPH-MJLGCCKJSA-N
SMILES: BrC1=C([C@@H]2NC3=C(C=CC=C3)[C@@]4([H])[C@]2([H])CC=C4)C=C5OCOC5=C1
Biological Activity: G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM[1][2].
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G15 | 99.0% | G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM. | ||||||||||||||||||||
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G15 (Standard) | ≥98% | G15 (Standard) is the analytical standard of G15 (HY-103449). This product is intended for research and analytical applications. G15 is a high affinity and selective G-protein-coupled estrogen receptor (GPER/GPR30) antagonist with a Ki of 20 nM. | ||||||||||||||||||||
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References
- [1]. Liu C, et al. G-Protein-Coupled Estrogen Receptor Antagonist G15 Decreases Estrogen-Induced Development of Non-Small Cell Lung Cancer. Oncol Res. 2019 Feb 21;27(3):283-292 [Content Brief]
- [2]. Girgert R, et al. Estrogen Signaling in ERα-Negative Breast Cancer: ERβ and GPER. Front Endocrinol (Lausanne). 2019 Jan 9;9:781. [Content Brief]
