1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. GPR30 agonist-1

GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects.

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GPR30 agonist-1 Chemical Structure

GPR30 agonist-1 Chemical Structure

CAS No. : 415919-74-3

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Solid + Solvent
10 mM * 1 mL in DMSO
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Description

GPR30 agonist-1 is a G protein-coupled receptor 30 (GPR30) agonist. GPR30 agonist-1 exerts vasorelaxant effects[1].

In Vivo

GPR30 agonist-1 (compound 5408-0877) (1 nM-10 μM) induces a concentration-dependent relaxation in carotid arteries from both male and female rats. GPR30 agonist-1-induced relaxation is abolished by endothelium removal and abrogated in the presence of the nitric oxide synthase inhibitor NG-nitro-l-arginine methyl ester (100 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

374.25

Formula

C19H17BrFNO

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC(C=C1)=C(C=C1Br)[C@@]2([H])[C@](CC=C3)([H])[C@]3([H])C4=CC(F)=CC=C4N2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (133.60 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6720 mL 13.3601 mL 26.7201 mL
5 mM 0.5344 mL 2.6720 mL 5.3440 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6720 mL 13.3601 mL 26.7201 mL 66.8003 mL
5 mM 0.5344 mL 2.6720 mL 5.3440 mL 13.3601 mL
10 mM 0.2672 mL 1.3360 mL 2.6720 mL 6.6800 mL
15 mM 0.1781 mL 0.8907 mL 1.7813 mL 4.4534 mL
20 mM 0.1336 mL 0.6680 mL 1.3360 mL 3.3400 mL
25 mM 0.1069 mL 0.5344 mL 1.0688 mL 2.6720 mL
30 mM 0.0891 mL 0.4453 mL 0.8907 mL 2.2267 mL
40 mM 0.0668 mL 0.3340 mL 0.6680 mL 1.6700 mL
50 mM 0.0534 mL 0.2672 mL 0.5344 mL 1.3360 mL
60 mM 0.0445 mL 0.2227 mL 0.4453 mL 1.1133 mL
80 mM 0.0334 mL 0.1670 mL 0.3340 mL 0.8350 mL
100 mM 0.0267 mL 0.1336 mL 0.2672 mL 0.6680 mL
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GPR30 agonist-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GPR30 agonist-1
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