2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. hFSH-β-(33-53)

hFSH-β-(33-53) is a polypeptide corresponding to residues 33-53 of hFSH-β, and also a follicle-stimulating hormone (FSH) antagonist. hFSH-β-(33-53) stimulates basal estradiol synthesis in cells. hFSH-β-(33-53) prolongs vaginal estrus in mice with normal estrous cycles.

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hFSH-β-(33-53)

hFSH-β-(33-53) Chemical Structure

CAS No. : 142154-55-0

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Based on 1 publication(s) in Google Scholar

Other Forms of hFSH-β-(33-53):

hFSH-β-(33-53) Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE hFSH-β-(33-53)

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

hFSH-β-(33-53) is a polypeptide corresponding to residues 33-53 of hFSH-β, and also a follicle-stimulating hormone (FSH) antagonist. hFSH-β-(33-53) stimulates basal estradiol synthesis in cells. hFSH-β-(33-53) prolongs vaginal estrus in mice with normal estrous cycles[1][2].

In Vitro

hFSH-β-(33-53) is a moderate-potency antagonist of hFSH; after radioiodination and alkylation modification, this peptide has a Kd of 5.5×10-5 M for the hFSH receptor[1].
hFSH-β-(33-53) inhibits the binding of [125I]hFSH to FSH receptors in calf testicular membranes[2].
hFSH-β-(33-53) regulates estradiol biosynthesis in primary rat Sertoli cells under basal conditions and/or FSH stimulation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

hFSH-β-(33-53) Related Antibodies
In Vivo

hFSH-β-(33-53) (4 mg/g body weight; i.p.; single injection) induces prolonged vaginal estrus in 50% of normally cycling adult female Swiss Webster mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster (female, 25-30 g, normally cycling, male-isolated)[2]
Dosage: 4 mg/g body weight
Administration: i.p.; single injection
Result: Induced prolonged vaginal estrus (≥48 hours without vaginal casts) in 50% of mice.
Maintained normal estrous cycles in 50% of treated mice.
Molecular Weight

2543.94

Formula

C115H183N31O32S
CAS No.
Appearance

Solid

Sequence

Tyr-Thr-Arg-Asp-Leu-Val-Tyr-Lys-Asp-Pro-Ala-Arg-Pro-Lys-Ile-Gln-Lys-Thr-Cys-Thr-Phe
Sequence Shortening

YTRDLVYKDPARPKIQKTCTF
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (9.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3931 mL 1.9655 mL 3.9309 mL
5 mM 0.0786 mL 0.3931 mL 0.7862 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3931 mL 1.9655 mL 3.9309 mL 9.8273 mL
5 mM 0.0786 mL 0.3931 mL 0.7862 mL 1.9655 mL
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hFSH-β-(33-53) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

hFSH-β-(33-53)142154-55-0Estrogen Receptor/ERRSwiss Webster miceestradiolbovine calf testis membranesfollicle-stimulating hormone receptorantiparallel β-sheetα-helical contentrat Sertoli cellsSertoli cellsvaginal estrusmiceInhibitorinhibitorinhibit

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