hFSH-β-(33-53)
Based on 1 publication(s) in Google Scholar
hFSH-β-(33-53) is a polypeptide corresponding to residues 33-53 of hFSH-β, and also a follicle-stimulating hormone (FSH) antagonist. hFSH-β-(33-53) stimulates basal estradiol synthesis in cells. hFSH-β-(33-53) prolongs vaginal estrus in mice with normal estrous cycles.
For research use only. We do not sell to patients.
- CAS No.: 142154-55-0
- Formula: C115H183N31O32S
- Molecular Weight:2543.94
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) hFSH-β-(33-53)
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Biological Activity
hFSH-β-(33-53) is a moderate-potency antagonist of hFSH; after radioiodination and alkylation modification, this peptide has a Kd of 5.5×10-5 M for the hFSH receptor[1].
hFSH-β-(33-53) inhibits the binding of [125I]hFSH to FSH receptors in calf testicular membranes[2].
hFSH-β-(33-53) regulates estradiol biosynthesis in primary rat Sertoli cells under basal conditions and/or FSH stimulation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss Webster (female, 25-30 g, normally cycling, male-isolated)[2]
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Dosage:4 mg/g body weight
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Administration:i.p.; single injection
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Result:Induced prolonged vaginal estrus (≥48 hours without vaginal casts) in 50% of mice.
Maintained normal estrous cycles in 50% of treated mice.
Chemical Information
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CAS No. 142154-55-0
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Appearance Solid
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Molecular Weight 2543.94
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Formula C115H183N31O32S
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Sequence
Tyr-Thr-Arg-Asp-Leu-Val-Tyr-Lys-Asp-Pro-Ala-Arg-Pro-Lys-Ile-Gln-Lys-Thr-Cys-Thr-Phe
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Sequence Shortening
YTRDLVYKDPARPKIQKTCTF
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Commun Biol
Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway. [Abstract]2024 Jul 10;7(1):844. PMID: 38987655
Solvent & Solubility
DMSO : 25 mg/mL (9.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Agris PF, et al. Solution structure of a synthetic peptide corresponding to a receptor binding region of FSH (hFSH-beta 33-53). J Protein Chem. 1992;11(5):495-507. [Content Brief]
[2]. Grasso P, et al. Cysteine residues in a synthetic peptide corresponding to human follicle-stimulating hormone beta-subunit receptor-binding domain 81-95 [hFSH-beta-(81-95)] modulate the in vivo effects of hFSH-beta-(81-95) on the mouse estrous cycle. Regul Pept. 1999;81(1-3):67-71. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.3931 mL | 1.9655 mL | 3.9309 mL | 9.8273 mL |
| 5 mM | 0.0786 mL | 0.3931 mL | 0.7862 mL | 1.9655 mL |
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