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AVE5688 

Cat. No.: HY-100320
Handling Instructions

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

For research use only. We do not sell to patients.

AVE5688 Chemical Structure

AVE5688 Chemical Structure

CAS No. : 613260-13-2

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Description

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

IC50 & Target

IC50: 430 nM (rmGPb), 915 nM (rmGPa)[1]
Kd: 170 nM (rmGPb), 530 nM (rmGPa)[1]

In Vitro

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively)[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Kinase Assay
[1]

Glycogen phosphorylase activity is measured in the physiological direction of glycogen breakdown. rmGP is used for the kinetic characterization of the inhibitors (AVE5688). To routinely check the phosphorylation grade of enzyme batches, activity is measured in the direction of glycogen synthesis; the phosphorylation grade is estimated from the ratio of the activity in the presence of 0.5 mM caffeine to the activity in the presence of 2 mM AMP[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

438.69

Formula

C₁₆H₈ClF₅N₂O₅

CAS No.

613260-13-2

SMILES

O=C(O)C1=CC=C(NC(NC(C2=CC(F)=C(F)C=C2Cl)=O)=O)C(OC(F)(F)F)=C1

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
AVE5688
Cat. No.:
HY-100320
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AVE5688

Cat. No.: HY-100320