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Cat. No.: HY-126756

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Amorphin

Amorphin is a phosphorylase b with glycogen metabolism activity. Amorphin binds directly to alpha-actinin, with alpha-actinin mediating its binding to actin filaments. Amorphin can be used for the research of McArdle’s disease and breast cancer.

For research use only. We do not sell to patients.

CAS No.: 4207-90-3
Formula: C₃₄H₄₀O₁₆
Molecular Weight:704.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Amorphin Chemical Structure

CAS No.: 4207-90-3

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

In Vitro

Amorphin (Compound 7) (68 h) selectively inhibits the proliferation of MCF-7 human breast cancer cells with an IC₅₀ of 0.95 μM, and has no effect on HCT-116 human colorectal cancer cells at concentrations up to 50 μM^[1].
Amorphin (1 μg/mL; 2 h at 4°C) directly binds to biotinylated alpha-actinin in a solid-phase dot blot assay^[2].
Amorphin (0.31-20 μg/mL; 15 min) binds with higher affinity to purified alpha-actinin than to purified F-actin in a solid-phase radioimmune assay^[2].
Amorphin (0.5 mg/mL; 5 min) binds to actin filaments only when they are decorated with purified alpha-actinin, as observed via negative stain electron microscopy^[2].
Amorphin binds specifically to the Z-bands of extracted glycerinated adult chicken pectoralis muscle myofibrils, restoring their electron-dense amorphous structure^[2].
Amorphin partial peptide sequencing confirms it is nearly identical to rabbit phosphorylase b, demonstrating amorphin is a phosphorylase b^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 4207-90-3
Molecular Weight 704.68
Formula C₃₄H₄₀O₁₆
SMILES

O=C1C=2C(=C3C(O[C@@H](C(CO[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@@H](O)[C@@H](O)CO5)[C@@H](O)[C@H](O)[C@H]4O)=C)C3)=CC2)O[C@]6([C@@]1(C=7C(OC6)=CC(OC)=C(OC)C7)[H])[H]
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wu X, et al. Cytotoxic rotenoid glycosides from the seeds of Amorpha fruticosa. Fitoterapia. 2015;100:75-80. [Content Brief]

[2]. Chowrashi P, et al. Amorphin is phosphorylase; phosphorylase is an alpha-actinin-binding protein. Cell Motil Cytoskeleton. 2002;53(2):125-135. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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