Glycogen phosphorylase-IN-1
Based on 1 Customer Validation
Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte glycogen-derived glucose production with IC50s of 53 and 380 nM, respectively. Glycogen phosphorylase-IN-1 reveals efficacy towards type 2 diabetes.
For research use only. We do not sell to patients.
- Purity: 98.15%
- CAS No.: 648926-15-2
- Formula: C17H15ClF2N4O4
- Molecular Weight:412.78
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Hepatocyte | IC50 |
0.38 μM
Compound: 42
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Inhibitory concentration against glucagon-induced glycogenolysis in rat primary hepatocytes upon incubation for 30 min at 37 degree C, pH 7.4 with compound dissolved in DMSO by 96-well plate assay
Inhibitory concentration against glucagon-induced glycogenolysis in rat primary hepatocytes upon incubation for 30 min at 37 degree C, pH 7.4 with compound dissolved in DMSO by 96-well plate assay
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[PMID: 16190745] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Glucagon-stimulated hyperglycemic in wistar rats[1]
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Dosage:5 mg/kg
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Administration:i.v., single dose
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Result:Reduced blood glucose.
Chemical Information
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CAS No. 648926-15-2
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Appearance Solid
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Molecular Weight 412.78
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Formula C17H15ClF2N4O4
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Color White to off-white
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SMILES
O=C(NC(NC1=CC(NC(NC)=O)=CC=C1OC)=O)C2=CC(F)=C(F)C=C2Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (266 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glycogen phosphorylase-IN-1 Related Classifications
HY-128029 Related Classifications
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