hUP1-IN-1 potassium

Name: hUP1-IN-1 potassium
Brand: MedChemExpress
SKU: HY-W017441A
Rating: 4.5 (1 reviews)

Cat. No.: HY-W017441A Purity: 99.54%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

hUP1-IN-1 potassium (compound 6a) is a hUP1 inhibitor with K_ii and K_is Urd of 375 and 635 nM. hUP1-IN-1 potassium showes inhibitory activities over hUP1 catalyzed reaction with 70% at 1 μM. hUP1-IN-1 potassium can be used for the research of cancer.

For research use only. We do not sell to patients.

hUP1-IN-1 potassium Chemical Structure

CAS No. : 118803-30-8

Size	Price	Stock	Quantity
50 mg	USD 450	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 630	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of hUP1-IN-1 potassium:

hUP1-IN-1 Get quote

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

188.23

Formula

C₇H₅KN₂O₂

CAS No.

118803-30-8

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(C)C=C(O[K])NC1=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (531.26 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.3126 mL	26.5632 mL	53.1265 mL
5 mM	1.0625 mL	5.3126 mL	10.6253 mL
10 mM	0.5313 mL	2.6563 mL	5.3126 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 3.75 mg/mL (19.92 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 3.75 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 3.75 mg/mL (19.92 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 3.75 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: 3.75 mg/mL (19.92 mM); Clear solution; Need ultrasonic

This protocol yields a clear solution of 3.75 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (37.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.54%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (250 KB) HNMR (138 KB) RP-HPLC (168 KB) LCMS (102 KB)

Handling Instructions (2659 KB)

References

[1]. Renck D, et al. Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem. 2013 Nov 14;56(21):8892-902. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.3126 mL	26.5632 mL	53.1265 mL	132.8162 mL
	5 mM	1.0625 mL	5.3126 mL	10.6253 mL	26.5632 mL
	10 mM	0.5313 mL	2.6563 mL	5.3126 mL	13.2816 mL
	15 mM	0.3542 mL	1.7709 mL	3.5418 mL	8.8544 mL
	20 mM	0.2656 mL	1.3282 mL	2.6563 mL	6.6408 mL
	25 mM	0.2125 mL	1.0625 mL	2.1251 mL	5.3126 mL
	30 mM	0.1771 mL	0.8854 mL	1.7709 mL	4.4272 mL
	40 mM	0.1328 mL	0.6641 mL	1.3282 mL	3.3204 mL
	50 mM	0.1063 mL	0.5313 mL	1.0625 mL	2.6563 mL
	60 mM	0.0885 mL	0.4427 mL	0.8854 mL	2.2136 mL
	80 mM	0.0664 mL	0.3320 mL	0.6641 mL	1.6602 mL
	100 mM	0.0531 mL	0.2656 mL	0.5313 mL	1.3282 mL