115066-04-1
Chemical Structure
α-NETA
- CAS No.: 115066-04-1
- Formula:C16H20INO
- Molecular Weight:369.24
IUPAC Name: N,N,N-trimethyl-3-(naphthalen-1-yl)-3-oxopropan-1-aminium iodide
InChIKey: QZXMJYVXMZJOAO-UHFFFAOYSA-M
SMILES: O=C(CC[N+](C)(C)C)C1=CC=CC2=C1C=CC=C2.[I-]
Biological Activity: α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity[1][2].
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α-NETA | ≥98.0% | α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC50 of 9 μM. α-NETA is a potent ALDH1A1 (IC50=0.04 µM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibits cholinesterase (ChE; IC50=84 µM) and acetylcholinesterase (AChE; IC50=300 µM). α-NETA has anti-cancer activity. | ||||||||||||||||||||
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- [1]. Sastry BV, et al. Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(alpha-naphthoyl)ethyltrimethylammonium and related compounds. Pharmacol Res Commun. 1988 Sep;20(9):751-71. [Content Brief]
- [2]. Graham KL, et al. A novel CMKLR1 small molecule antagonist suppresses CNS autoimmune inflammatory disease. PLoS One. 2014 Dec 1;9(12):e112925. [Content Brief]
Keywords
