120014-06-4
120014-06-4
Chemical Structure
Donepezil
Synonym(s): E2020 free base
- CAS No.: 120014-06-4
- Formula:C24H29NO3
- Molecular Weight:379.49
IUPAC Name: 2-((1-benzylpiperidin-4-yl)methyl)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one
InChIKey: ADEBPBSSDYVVLD-UHFFFAOYSA-N
SMILES: O=C(C(C=C(OC)C(OC)=C1)=C1C2)C2CC(CC3)CCN3CC4=CC=CC=C4
Biological Activity: Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
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Donepezil | 99.82% | Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Donepezil (Standard) | ≥98% | Donepezil (Standard) is the analytical standard of Donepezil. This product is intended for research and analytical applications. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Donepezil-d4 | Donepezil-d4 (E2020-d4 (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | |||||||||||||||||||||
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Donepezil-d5 | 99.30% | Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Donepezil-d7 | Donepezil-d7 (E2020-d7 (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-136838(R)-Donepezil -
Similarity Score 1.00
HY-14566A(S)-Donepezil -
Similarity Score 0.98
HY-B0034SDonepezil-d5 hydrochloride -
Similarity Score 0.98
HY-B0034Donepezil Hydrochloride -
Similarity Score 0.90
HY-133926S5-O-Desmethyl donepezil-d5 -
Similarity Score 0.90
HY-133925S6-O-Desmethyl donepezil-d5 -
Similarity Score 0.89
HY-1339265-O-Desmethyl donepezil -
Similarity Score 0.89
HY-1339256-O-Desmethyl donepezil -
Similarity Score 0.81
HY-134137Donepezil N-oxide -
Explore the MedChemAI to find more analogs
