1. Neuronal Signaling
  2. Cholinesterase (ChE)
  3. Donepezil-d5

Donepezil-d5 (Synonyms: E2020-d5)

Cat. No.: HY-14566S1 Purity: ≥99.0%
Handling Instructions

Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively.

For research use only. We do not sell to patients.

Donepezil-d5 Chemical Structure

Donepezil-d5 Chemical Structure

CAS No. : 1128086-25-8

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1 mg USD 950 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

384.52

Formula

C24H24D5NO3

CAS No.
SMILES

O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)CC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥99.0%

References
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Donepezil-d5
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