1128086-25-8
1128086-25-8
Chemical Structure
Donepezil-d5
Synonym(s): E2020-d5 free base
- CAS No.: 1128086-25-8
- Formula:C24H24D5NO3
- Molecular Weight:384.52
IUPAC Name: 5,6-dimethoxy-2-((1-((phenyl-d5)methyl)piperidin-4-yl)methyl)-2,3-dihydro-1H-inden-1-one
InChIKey: ADEBPBSSDYVVLD-DKFMXDSJSA-N
SMILES: O=C1C2=CC(OC)=C(OC)C=C2CC1CC3CCN(CC3)CC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H]
Biological Activity: Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively[1].
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Donepezil-d5 | 99.30% | Donepezil-d5 is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Donepezil (Standard) | ≥98% | Donepezil (Standard) is the analytical standard of Donepezil. This product is intended for research and analytical applications. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Donepezil-d4 | Donepezil-d4 (E2020-d4 (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | |||||||||||||||||||||
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Donepezil-d7 | Donepezil-d7 (E2020-d7 (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | |||||||||||||||||||||
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Donepezil | 99.82% | Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC50s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 1.00
HY-136838(R)-Donepezil -
Similarity Score 1.00
HY-14566A(S)-Donepezil -
Similarity Score 0.98
HY-B0034SDonepezil-d5 hydrochloride -
Similarity Score 0.98
HY-B0034Donepezil Hydrochloride -
Similarity Score 0.90
HY-133926S5-O-Desmethyl donepezil-d5 -
Similarity Score 0.90
HY-133925S6-O-Desmethyl donepezil-d5 -
Similarity Score 0.89
HY-1339265-O-Desmethyl donepezil -
Similarity Score 0.89
HY-1339256-O-Desmethyl donepezil -
Similarity Score 0.81
HY-134137Donepezil N-oxide -
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