1. Neuronal Signaling
  2. AChE
  3. Donepezil Hydrochloride

Donepezil Hydrochloride (Synonyms: E2020)

Cat. No.: HY-B0034 Purity: 99.97%
Handling Instructions

Donepezil (Hydrochloride) (E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine.

For research use only. We do not sell to patients.

Donepezil Hydrochloride Chemical Structure

Donepezil Hydrochloride Chemical Structure

CAS No. : 120011-70-3

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
50 mg USD 72 In-stock
Estimated Time of Arrival: December 31
100 mg USD 96 In-stock
Estimated Time of Arrival: December 31
200 mg USD 144 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
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Description

Donepezil (Hydrochloride) (E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine. IC50 Value: Target: AChE It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats.

Clinical Trial
Molecular Weight

415.95

Formula

C₂₄H₃₀ClNO₃

CAS No.

120011-70-3

SMILES

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=C1C=C(OC)C(OC)=C4.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (80.13 mM; Need ultrasonic)

DMSO : 6.2 mg/mL (14.91 mM; Need warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4041 mL 12.0207 mL 24.0414 mL
5 mM 0.4808 mL 2.4041 mL 4.8083 mL
10 mM 0.2404 mL 1.2021 mL 2.4041 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.97%

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Keywords:

DonepezilE2020E 2020E-2020AChEAcetylcholinesteraseInhibitorinhibitorinhibit

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Product Name:
Donepezil Hydrochloride
Cat. No.:
HY-B0034
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