1. Neuronal Signaling
  2. AChE
  3. Pyridostigmine bromide

Pyridostigmine bromide 

Cat. No.: HY-B0207A Purity: >98.0%
Handling Instructions

Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor.

For research use only. We do not sell to patients.

Pyridostigmine bromide Chemical Structure

Pyridostigmine bromide Chemical Structure

CAS No. : 101-26-8

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Description

Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. Target: AChE Pyridostigmine bromide is a parasympathomimetic and a reversible cholinesterase inhibitor. Since it is a quaternary amine, it is poorly absorbed in the gut and does not cross the blood–brain barrier, except possibly in stressful conditions. Pyridostigmine bromide inhibits acetylcholinesterase in the synaptic cleft, thus slowing down the hydrolysis of acetylcholine. It is a quaternary carbamate inhibitor of cholinesterase that does not cross the blood–brain barrier which carbamylates about 30% of peripheral cholinesterase enzyme. The carbamylated enzyme eventually regenerates by natural hydrolysis and excess ACh levels revert to normal. Pyridostigmine bromide is used to treat muscle weakness in people with myasthenia gravis and to combat the effects of curariform drug toxicity. Pyridostigmine bromide has been FDA approved for military use during combat situations as an agent to be given prior to exposure to the nerve agent Soman in order to increase survival. Used in particular during the first Gulf War, pyridostigmine bromide has been implicated as a causal factor in Gulf War syndrome. Pyridostigmine bromide sometimes is used to treat orthostatic hypotension. It may also be of benefit in chronic axonal polyneuropathy.

Clinical Trial
Molecular Weight

261.12

Formula

C₉H₁₃BrN₂O₂

CAS No.

101-26-8

SMILES

C[N+]1=CC=CC(OC(N(C)C)=O)=C1.[Br-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 8.8 mg/mL (33.70 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8297 mL 19.1483 mL 38.2966 mL
5 mM 0.7659 mL 3.8297 mL 7.6593 mL
10 mM 0.3830 mL 1.9148 mL 3.8297 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

PyridostigmineAChEAcetylcholinesteraseInhibitorinhibitorinhibit

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Pyridostigmine bromide
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