2. Signaling Pathways
  3. Neuronal Signaling
  4. Cholinesterase (ChE)
  5. AChE Isoform
  6. AChE Activator

AChE Activator

AChE Activators (7):

Cat. No. Product Name Effect Purity
  • HY-B1200
    Pralidoxime chloride
    		Activator 99.98%
    Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning.
  • HY-B1738A
    Pralidoxime iodide
    		Activator 98.0%
    Pralidoxime iodide is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime iodide reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime iodide is an antidote for organophosphate poisoning.
  • HY-B1738
    Pralidoxime
    		Activator
    Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning.
  • HY-146959
    K203
    		Activator
    K203 is a potent reactivator of tabun-inhibited AChE. K203 is a crucial antidote used for the organophosphate intoxication.
  • HY-177958
    ACS03
    		Activator
    ACS03 is a hybrid thiophene-acridine compound. ACS03 induces an increase in lactate dehydrogenase, glutathione S-transferase, and AChE activities. ACS03 has antileishmanial activity. ACS03 exhibits selective anti-cancer effects against colon carcinoma.
  • HY-180141
    AF03
    		Activator
    AF03 is a larvicide against Aedes aegypti Vector Larvae with a LC50 of 41.6 μg/mL. AF03 binds stably to the sterol carrier protein-2 (AeSCP-2) of Aedes aegypti, interfering with lipid metabolism in larvae. AF03 can increase acetylcholinesterase (AChE) activity in the zebrafish brain, slightly elevate catalase (CAT) activity in the liver and heart, and increased superoxide dismutase (SOD) activity in the brain. AF03 can be used for the research of arboviruses infection, such as Dengue.
  • HY-165600
    Trimedoxime dichloride
    		Activator
    Trimedoxime dichloride (TMB-4 dichloride) is a blood-brain barrier-permeable cholinesterase reactivator. Trimedoxime dichloride reactivates cholinesterase inhibited by paraoxon, sarin, tabun and other agents, restricts the breakdown of acetylcholine and alleviates excessive cholinergic stimulation. Trimedoxime dichloride reduces mortality and prolongs survival time. Trimedoxime dichloride exhibits reactivation efficacy against AChE in rat tissues. Trimedoxime dichloride can be used in research related to organophosphate (paraoxon) poisoning and tabun poisoning.