2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. JDS364

JDS364 is a blood-brain barrier-permeable human acetylcholinesterase (hAChE) reactivator with an IC50 of 8.6 μM. JDS364 achieves rapid systemic exposure in mice and acts as a protective agent when used in combination with Atropine (HY-B1205). JDS364 can be used in studies on organophosphate nerve agent poisoning and organophosphate pesticide poisoning.

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JDS364

JDS364 Chemical Structure

CAS No. : 2072857-15-7

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JDS364 Related Antibodies

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Description

JDS364 is a blood-brain barrier-permeable human acetylcholinesterase (hAChE) reactivator with an IC50 of 8.6 μM. JDS364 achieves rapid systemic exposure in mice and acts as a protective agent when used in combination with Atropine (HY-B1205). JDS364 can be used in studies on organophosphate nerve agent poisoning and organophosphate pesticide poisoning[1].

IC50 & Target[1]

hAChE

8.6 μM (IC50)

In Vitro

JDS364 demonstrates broad-spectrum, high-efficiency reactivation of hAChE inhibited by nerve agent surrogates and paraoxon, with exceptional efficacy against tabun surrogate-inhibited hAChE[1].
JDS364 (50 μM) exhibits high permeability across a validated human in vitro BBB model without causing cytotoxicity or barrier disruption, confirming its potential for CNS penetration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JDS364 Related Antibodies
Parmacokinetics
Species Dose Route Tmax MRT
Mice[1] 100 μmol/Kg i.p. 4.5 min 33.1 min
In Vivo

JDS364 (100 μmol/kg; i.p.; single dose; 1 minute post-agent challenge) provides significant protection against organophosphorus poisoning in mice, with a maximum protective index of 6.7 when combined with atropine against paraoxon challenge[1].
JDS364 (100 μmol/kg; i.p.; single dose) exhibits rapid and efficient functional bioavailability in mouse blood, reaching peak reactivation capacity within 5 minutes of intraperitoneal administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss mice (male, 9 weeks old, 35-45 g)[1]
Dosage: 100 μmol/kg (monotherapy); 100 μmol/kg + 10 mg/kg atropine (combination therapy)
Administration: i.p.; single dose; 1 minute post-agent challenge
Result: Achieved a protective index (PI) of 2.6 against paraoxon, 1.3 against NIMP, and 1.5 against NEMP when administered alone.
Exhibited a PI of 6.7 against paraoxon, 2.7 against NIMP, and 3.7 against NEMP when combined with atropine.
Had a median lethal dose (LD50) of 364 μmol/kg via intraperitoneal administration.
Molecular Weight

336.39

Formula

C19H20N4O2
CAS No.
SMILES

OC1=CC=C(CCCCNC2=CC=NC3=CC=CC=C23)N=C1/C=N/O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JDS364 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JDS3642072857-15-7JDS 364JDS-364Cholinesterase (ChE)Tyr449blood-brain barrierTcAChEhAChEhuman acetylcholinesterasesarin-inhibited hAChEorganophosphorus pesticide poisoningorganophosphorus nerve agent poisoningVX-inhibited hAChEmiceInhibitorinhibitorinhibit

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