1. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  2. mAChR
    Endogenous Metabolite
  3. Atropine

Atropine (Synonyms: Tropine tropate; DL-Hyoscyamine)

Cat. No.: HY-B1205 Purity: 99.49%
Handling Instructions

Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist, with anti-myopia effect. Atropine blocks the inhibitory effect of ACh on heart rate and contractility, potentially also leading to tachyarrhythmias.

For research use only. We do not sell to patients.

Atropine Chemical Structure

Atropine Chemical Structure

CAS No. : 51-55-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 Get quote
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of Atropine:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Atropine (Tropine tropate) is a competitive muscarinic acetylcholine receptor (mAChR) antagonist, with anti-myopia effect. Atropine blocks the inhibitory effect of ACh on heart rate and contractility, potentially also leading to tachyarrhythmias[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Atropine increases cAMP independently of M1/2/3-muscarinic receptors in cardiomyocytes[1].
Atropine inhibits the cAMP-specific phosphodiesterase PDE4 in cardiomyocytes[1].
Atropine might inhibit myopia via α2A-adrenoceptors, , instead of through the mAChR M4/cM4 receptor subtype[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4 (PDE4)[1].
Atropine (30-60 mg/kg/day; s.c.) causes changes in mouse motility that is not correlates to its modification of ACh levels in the CNS[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female albino Swiss Morini mice (20-25 g)[2]
Dosage: 30 mg/kg, 40 mg/kg, 60 mg/kg
Administration: Subcutaneous injection; daily
Result: Chronic administration of atropine caused significant increase of motility at doses which caused no modification of ACh levels.
Clinical Trial
Molecular Weight

289.37

Formula

C₁₇H₂₃NO₃

CAS No.
SMILES

O=C(O[[email protected]@H]1C[[email protected]@H](N2C)CC[[email protected]@H]2C1)C(CO)C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under argon

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under argon)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 96.6 mg/mL (333.83 mM)

H2O : 2.9 mg/mL (10.02 mM; Need ultrasonic and warming)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4558 mL 17.2789 mL 34.5578 mL
5 mM 0.6912 mL 3.4558 mL 6.9116 mL
10 mM 0.3456 mL 1.7279 mL 3.4558 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (7.19 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (7.19 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (7.19 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.55%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AtropineTropine tropate DL-HyoscyaminemAChREndogenous MetaboliteMuscarinic acetylcholine receptoranti-myopiatachyarrhythmiasInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Atropine
Cat. No.:
HY-B1205
Quantity:
MCE Japan Authorized Agent: