Atropine hydrobromide
Based on 27 publication(s) in Google Scholar
Atropine (Tropine tropate) hydrobromide is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine hydrobromide inhibits ACh-induced relaxations in human pulmonary veins. Atropine hydrobromide can be used for research of anti-myopia and bradycardia.
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- CAS No.: 6415-90-3
- Formule: C17H24BrNO3
- Masse moléculaire:370.28
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Publications Citing Use of MedChemExpress (MCE) Atropine hydrobromide
More- Cell. 2025 Nov 26;188(24):6754-6773.e29. [Abstract]
- Cell Metab. 2022 Dec 6;34(12):1999-2017.e10. [Abstract]
- Cell Stem Cell. 2026 May 15:S1934-5909(26)00158-X. [Abstract]
- Kidney Int. 2026 Jan 19:S0085-2538(26)00008-6. [Abstract]
- Sci Adv. 2025 Dec 5;11(49):eadw7972. [Abstract]
- Small. 2026 Jan 21:e06988. [Abstract]
- J Neuroinflammation. 2026 May 25. [Abstract]
- J Hazard Mater. 2024 Nov 5:479:135690. [Abstract]
- J Hazard Mater. 2024 Mar 5:465:133248. [Abstract]
- Food Chem. 2022 Nov 30:395:133593. [Abstract]
- J Transl Med. 2025 Jan 23;23(1):112. [Abstract]
- Cell Rep. 2026 Mar 24;45(3):117086. [Abstract]
- Cell Rep. 2022 Mar 8;38(10):110468. [Abstract]
- J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
- Eur J Pharmacol. 2024 Nov 15:983:176954. [Abstract]
- Front Pharmacol. 2020 Jul 31:11:1038. [Abstract]
- Insect Biochem Mol Biol. 2026 Sep:194:104634.
- Am J Physiol Renal Physiol. 2024 Nov 1;327(5):F885-F898. [Abstract]
- Cardiovasc Drugs Ther. 2025 Apr 7. [Abstract]
- Vet Microbiol. 2026 May:316:110992. [Abstract]
- J Chromatogr B Analyt Technol Biomed Life Sci. 2026 Oct 1:1282:125245.
- Arch Oral Biol. 2023 Jan:145:105586. [Abstract]
- Can J Physiol Pharmacol. 2020 Oct;98(10):725-732. [Abstract]
- J Biosci. 2021:46:90. [Abstract]
- Research Square Print. 2023 Feb 7.
- Research Square Print. December 16th, 2022.
- Research Square Preprint. 2022 Mar.
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Activité biologique
Description
IC50 & Target
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mAChR4 |
In Vitro
Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) hydrobromide inhibits ACh-induced relaxations in human pulmonary veins[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:White-footed mice (Peromyscus sp.)[2]
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Dosage:10 mg/kg
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Administration:Intraperitoneal injection; once, for 40 minutes
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Result:Increased heart rate was a decrease in cardiac arrhythmia.
Chemical Information
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CAS No. 6415-90-3
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Masse moléculaire 370.28
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Formule C17H24BrNO3
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SMILES
O=C(O[C@@H]1C[C@@H](N2C)CC[C@@H]2C1)C(CO)C3=CC=CC=C3.Br
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Synonyms
Tropine tropate hydrobromide; DL-Hyoscyamine hydrobromide
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (27)
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Journal Impact Factor
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Most Recent
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Cell
2025 Nov 26;188(24):6754-6773.e29. PMID: 41138728 -
Cell Metab
Cancer cells co-opt nociceptive nerves to thrive in nutrient-poor environments and upon nutrient-starvation therapies. [Abstract]2022 Dec 6;34(12):1999-2017.e10. PMID: 36395769 -
Cell Stem Cell
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. [Abstract]2026 May 15:S1934-5909(26)00158-X. PMID: 42143017 -
Kidney Int
2026 Jan 19:S0085-2538(26)00008-6. PMID: 41565024 -
Sci Adv
EphB1-NR2B receptor signaling in glutamatergic neurons of the ventroposteromedial thalamic nucleus regulates emergence from anesthesia. [Abstract]2025 Dec 5;11(49):eadw7972. PMID: 41348875 -
Small
A Balloon Electrochemical Sensor for Conformal Interfacing With Intestinal Wall and Real-Time Monitoring of Serotonin Release. [Abstract]2026 Jan 21:e06988. PMID: 41563114 -
J Neuroinflammation
PVNOXT regulates acinar cell-mediated inflammatory response via DMVACh projections to the acinar cell. [Abstract]2026 May 25. PMID: 42186091 -
J Hazard Mater
β-ionone inhibits the grazing of Daphnia sinensis by reducing the activity of acetylcholinesterase. [Abstract]2024 Nov 5:479:135690. PMID: 39255669 -
J Hazard Mater
β-cyclocitral, a novel AChE inhibitor, contributes to the defense of Microcystis aeruginosa against Daphnia grazing. [Abstract]2024 Mar 5:465:133248. PMID: 38147752 -
Food Chem
Screening of bioactive flavour compounds targeting muscarinic-3 acetylcholine receptor from Siraitia grosvenorii and evaluation of their synergistic anti-asthmatic activity. [Abstract]2022 Nov 30:395:133593. PMID: 35792488 -
J Transl Med
Increased nerve density adversely affects outcome in colorectal cancer and denervation suppresses tumor growth. [Abstract]2025 Jan 23;23(1):112. PMID: 39849539 -
Cell Rep
2026 Mar 24;45(3):117086. PMID: 41831232 -
Cell Rep
Moderate heart rate reduction promotes cardiac regeneration through stimulation of the metabolic pattern switch. [Abstract]2022 Mar 8;38(10):110468. PMID: 35263588 -
J Ethnopharmacol
Cholinergic signaling of muscarinic receptors directly involves in the neuroprotection of muscone by inducing Ca2+ antagonism and maintaining mitochondrial function. [Abstract]2024 Jan 30;319(Pt 2):117192. PMID: 37734472
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Representative images of TTC-stained brain coronal sections of rats.
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Western blot results of signal pathways.
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Statistical results of neurological score by mNSS.
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: J Ethnopharmacol. 2024 Jan 30;319(Pt 2):117192. [Abstract]
Atropine (0.5 mg/kg; ip). Statistical results of Western blot in AKT/p-AKT.
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Eur J Pharmacol
Activation of Piezo1 channels enhances spontaneous contractions of isolated human bladder strips via acetylcholine release from the mucosa. [Abstract]2024 Nov 15:983:176954. PMID: 39237075
Atropine hydrobromide purchased from MedChemExpress. Usage Cited in: Eur J Pharmacol. 2024 Nov 15:983:176954. [Abstract]
Yoda1-induced ATP release was significantly attenuated in the presence of Atropine (1 μM).
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Front Pharmacol
Eye Drops of Metformin Prevents Fibrosis After Glaucoma Filtration Surgery in Rats via Activating AMPK/Nrf2 Signaling Pathway. [Abstract]2020 Jul 31:11:1038. PMID: 32903813 -
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Am J Physiol Renal Physiol
Anatomic and functional evidence for renal autonomic innervation in normotensive and hypertensive rats. [Abstract]2024 Nov 1;327(5):F885-F898. PMID: 39298550 -
Cardiovasc Drugs Ther
Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Heart Failure with Preserved Ejection Fraction Through Regulating Macrophage Polarization Mediated by Alpha7nAChR. [Abstract]2025 Apr 7. PMID: 40193005 -
Vet Microbiol
The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]2026 May:316:110992. PMID: 41865607 -
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Arch Oral Biol
Parasympathetic-macrophages-ductal epithelial cells axis promotes female rat submandibular gland regeneration after excretory duct ligation/deligation. [Abstract]2023 Jan:145:105586. PMID: 36410162 -
Can J Physiol Pharmacol
2020 Oct;98(10):725-732. PMID: 32516556 -
J Biosci
M1 macrophages-derived exosomes miR-34c-5p regulates interstitial cells of Cajal through targeting SCF. [Abstract]2021:46:90. PMID: 34544909 -
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Pureté et documentation
Références
[1]. McBrien NA, et, al. How does atropine exert its anti-myopia effects? Ophthalmic Physiol Opt. 2013 May;33(3):373-8. [Content Brief]
[2]. Morhardt JE. Heart rates, breathing rates and the effects of atropine and acetylcholine on white-footed mice (Peromyscus sp.) during daily torpor. Comp Biochem Physiol. 1970 Mar 15;33(2):441-57. [Content Brief]
[3]. Carr BJ, et, al. Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. [Content Brief]
[4]. Walch L, et, al. Evidence for a M(1) muscarinic receptor on the endothelium of human pulmonary veins. Br J Pharmacol. 2000 May;130(1):73-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Atropine hydrobromide Related Classifications
HY-B1205B Related Classifications
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