1. GPCR/G Protein Neuronal Signaling
  2. mAChR
  3. Atropine sulfate monohydrate

Atropine sulfate monohydrate  (Synonyms: Tropine tropate sulfate monohydrate; DL-Hyoscyamine sulfate monohydrate)

Cat. No.: HY-B0394 Purity: 99.68%
COA Handling Instructions

Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia.

For research use only. We do not sell to patients.

Atropine sulfate monohydrate Chemical Structure

Atropine sulfate monohydrate Chemical Structure

CAS No. : 5908-99-6

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10 mM * 1 mL in DMSO
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Based on 14 publication(s) in Google Scholar

Other Forms of Atropine sulfate monohydrate:

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Description

Atropine (Tropine tropate) sulfate monohydrate is a competitive muscarinic acetylcholine receptor (mAChR) antagonist with IC50 values of 0.39 and 0.71 nM for Human mAChR M4 and Chicken mAChR M4, respectively. Atropine sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins. Atropine sulfate monohydrate can be used for research of anti-myopia and bradycardia[1][2][3][4].

IC50 & Target

mAChR4

 

In Vitro

Atropine (Tropine tropate; 1 μM; pulmonary veins and arteries) sulfate monohydrate inhibits ACh-induced relaxations in human pulmonary veins[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Atropine (Tropine tropate; 10 mg/kg; i.p.; once, for 40 minutes; Peromyscus sp.) sulfate monohydrate inhibits the cardiac arrhythmia which normally occurs throughout torpor[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: White-footed mice (Peromyscus sp.)[2]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; once, for 40 minutes
Result: Increased heart rate was a decrease in cardiac arrhythmia.
Clinical Trial
Molecular Weight

347.43

Formula

C17H27NO8S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=[S](O)(O)=O.O=C(C(C1=CC=CC=C1)CO)O[C@H]2C[C@@H](CC3)N(C)[C@@H]3C2.O

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (143.91 mM; Need ultrasonic)

H2O : 33.33 mg/mL (95.93 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8783 mL 14.3914 mL 28.7828 mL
5 mM 0.5757 mL 2.8783 mL 5.7566 mL
10 mM 0.2878 mL 1.4391 mL 2.8783 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (287.83 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.20 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.20 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (7.20 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.68%

References
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Atropine sulfate monohydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Atropine sulfate monohydrate
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HY-B0394
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