1. GPCR/G Protein
    Autophagy
  2. Cannabinoid Receptor
    Autophagy

Pregnenolone (Synonyms: Arthenolone; 3β-Hydroxy-5-pregnen-20-one)

Cat. No.: HY-B0151 Purity: >98.0%
Handling Instructions

Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively.

For research use only. We do not sell to patients.
Pregnenolone Chemical Structure

Pregnenolone Chemical Structure

CAS No. : 145-13-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
1 g USD 60 In-stock
5 g USD 96 In-stock
10 g   Get quote  
50 g   Get quote  

* Please select Quantity before adding items.

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Pregnenolone is an endogenous steroid hormone for inhibition of M1 receptor and M3 receptor-mediated currents with IC50 of 11.4 μM and 6.0 μM, respectively. Target: M1 receptor; M3 receptor Pregnenolone is an endogenous steroid hormone involved in the steroidogenesis of progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. Pregnenolone and its sulfate, like DHEA and its sulfate and progesterone, belong to the group of neurosteroids that are found in high concentrations in certain areas of the brain, and are synthesized there. Neurosteroids affect synaptic functioning, are neuroprotective, and enhance myelinization. Pregnenolone and its sulfate ester are under investigation for their potential to improve cognitive and memory functioning. Pregnenolone is also being considered as a potential treatment for schizophrenia.

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 3.1598 mL 15.7988 mL 31.5976 mL
5 mM 0.6320 mL 3.1598 mL 6.3195 mL
10 mM 0.3160 mL 1.5799 mL 3.1598 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

316.48

Formula

C₂₁H₃₂O₂

CAS No.

145-13-1

SMILES

C[[email protected]@](C1=CC2)(CC[[email protected]](O)C1)[[email protected]]3([H])[[email protected]]2([H])[[email protected]@](CC[[email protected]@H]4C(C)=O)([H])[[email protected]]4(C)CC3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pregnenolone
Cat. No.:
HY-B0151
Quantity: