1. Metabolic Enzyme/Protease
    GPCR/G Protein
    Autophagy
  2. Endogenous Metabolite
    Cannabinoid Receptor
    Autophagy

Pregnenolone monosulfate (Synonyms: Pregn-5-en-20-on-3β-yl sulfuric acid)

Cat. No.: HY-B1739
Handling Instructions

Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).

For research use only. We do not sell to patients.

Pregnenolone monosulfate Chemical Structure

Pregnenolone monosulfate Chemical Structure

CAS No. : 1247-64-9

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Other Forms of Pregnenolone monosulfate:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

Pregnenolone monosulfate acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).

IC50 & Target[1]

CB1 Receptor

 

Human Endogenous Metabolite

 

In Vitro

The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1].

In Vivo

Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5218 mL 12.6091 mL 25.2181 mL
5 mM 0.5044 mL 2.5218 mL 5.0436 mL
10 mM 0.2522 mL 1.2609 mL 2.5218 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1]

Mice and Rats[1]
Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

396.54

Formula

C₂₁H₃₂O₅S

CAS No.

1247-64-9

SMILES

CC([[email protected]]1CC[[email protected]@]2([H])[[email protected]]3([H])CC=C4C[[email protected]@H](OS(=O)(O)=O)CC[[email protected]]4(C)[[email protected]@]3([H])CC[[email protected]]12C)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Pregnenolone monosulfate
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Pregnenolone monosulfate

Cat. No.: HY-B1739