1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    GPCR/G Protein
    Immunology/Inflammation
  2. nAChR
    Histamine Receptor
  3. Mecamylamine hydrochloride

Mecamylamine hydrochloride 

Cat. No.: HY-B1395 Purity: ≥98.0%
COA Handling Instructions

Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area.

For research use only. We do not sell to patients.

Mecamylamine hydrochloride Chemical Structure

Mecamylamine hydrochloride Chemical Structure

CAS No. : 826-39-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 135 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 135 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 115 In-stock
Estimated Time of Arrival: December 31
25 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 400 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Mecamylamine hydrochloride:

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[1][2][5].

IC50 & Target

nAChR[1], histamine receptor[2]

In Vitro

Mecamylamine (0.5-9 μM, bath administered) increases the firing frequency of identified 5-HT DRN (dorsal raphe nucleus) neurons[1].
Mecamylamine (0.5-9 μM, bath administered) increases the glutamatergic and decreases the GABAergic input of 5-HT DRN neurons[1].
Mecamylamine (1 mM, 5 min) blocks the histamine receptor and the histamine-induced contractions in helically cut strips of rabbit aorta[2].
Mecamylamine (10 μM,48 h) attenuates the effect of nicotine’s action of neuroprotection[3].
Mecamylamine (1-100 nM, 30 min) dose-dependently attenuates endothelial tube formation in HDMVECs[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: SCG neurons
Concentration: 10 μM
Incubation Time: 48 h
Result: Reduced the nicotine-facilitated increase in ERK1/2.
In Vivo

Mecamylamine (subcutaneous pumps, 50 mg/kg/day, 2 days) inhibits Choroidal neovascularization (CNV) in CNV mice model[4].
Mecamylamine (intraperitoneal injection, 0.5-1 mg/kg) has antidepressant-like effects in both the TST (tail suspension test) and FST (forced swim test) in C57BL/6J mice, which are dependent on both β2 and α7 subunits[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Choroidal neovascularization (CNV) mice model[1]
Dosage: 50 mg/kg/day, 2 days
Administration: Subcutaneous pumps implanted beneath the skin of the back, 200 μL and mean pumping rate of 0.5 μL/h.
Result: Suppressed the development of CNV at Bruch’s membrane rupture sites in the absence of nicotine.
Animal Model: C57BL/6J mice[5]
Dosage: 0.5-1 mg/kg
Administration: Intraperitoneal injection
Result: Had no effect in β2 knockout mice and α7 knockout mice, but decreased immobility time in wildtype littermates in the FST.
Clinical Trial
Molecular Weight

203.75

Formula

C11H22ClN

CAS No.
SMILES

CC1(C)C(NC)(C)C2CCC1C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (490.80 mM; Need ultrasonic)

DMSO : 31.25 mg/mL (153.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9080 mL 24.5399 mL 49.0798 mL
5 mM 0.9816 mL 4.9080 mL 9.8160 mL
10 mM 0.4908 mL 2.4540 mL 4.9080 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (10.21 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (10.21 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (10.21 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Product Name:
Mecamylamine hydrochloride
Cat. No.:
HY-B1395
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