6735-59-7
6735-59-7
Chemical Structure
Pralidoxime
- CAS No.: 6735-59-7
- Formula:C7H9N2O+
- Molecular Weight:137.16
IUPAC Name: (E)-2-((hydroxyimino)methyl)-1-methylpyridin-1-ium
InChIKey: JBKPUQTUERUYQE-UHFFFAOYSA-O
SMILES: C[N+]1=CC=CC=C1/C=N/O
Biological Activity: Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning[1][2].
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Pralidoxime | Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning. | |||||||||||||||||||||
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References
- [1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [Content Brief]
- [2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [Content Brief]
Keywords
