607-28-3
Chemical Structure
Isatin-O
Synonym(s): Isatin β-oxime; Isatin 3-oxime
- CAS. Nr.: 607-28-3
- Formula:C8H6N2O2
- Molecular Weight:162.15
IUPAC Name: (Z)-3-(hydroxyimino)indolin-2-one
InChIKey: LNMAXZZQNSPQSR-UHFFFAOYSA-N
SMILES: O=C1NC=2C=CC=CC2C1=NO
Biological Activity: Isatin-O (Isatin β-oxime; Isatin 3-oxime) is an acetylcholinesterase (AChE) reactivator capable of crossing the blood-brain barrier. Isatin-O reactivates paraoxon-inhibited acetylcholinesterase in the central and peripheral nervous systems. As a glycosylation substrate, Isatin-O undergoes complete glycosylation in a Rauvolfia serpentina cell suspension culture system to form isatin-3-oxime-glucoside. Isatin-O can be used in studies related to organophosphate poisoning[1][2].
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Isatin-O | Isatin-O (Isatin β-oxime; Isatin 3-oxime) is an acetylcholinesterase (AChE) reactivator capable of crossing the blood-brain barrier. Isatin-O reactivates paraoxon-inhibited acetylcholinesterase in the central and peripheral nervous systems. As a glycosylation substrate, Isatin-O undergoes complete glycosylation in a Rauvolfia serpentina cell suspension culture system to form isatin-3-oxime-glucoside. Isatin-O can be used in studies related to organophosphate poisoning. | |||||||||||||||||||||
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References
- [1]. de Paula RL, et al. Molecular Modeling and In Vitro Studies of a Neutral Oxime as a Potential Reactivator for Acetylcholinesterase Inhibited by Paraoxon. Molecules (Basel, Switzerland). 2018 Nov 12;23(11):2954. [Content Brief]
- [2]. Hinse C, et al. Glucosylation of isatin-3-oxime followed by 2D in situ NMR in plant cells at highest magnetic field without labelling. Natural product letters. 2001;15(2):119-24. [Content Brief]
