51-15-0
51-15-0
Chemical Structure
Pralidoxime chloride
Synonym(s): 2-PAM chloride
- CAS No.: 51-15-0
- Formula:C7H9ClN2O
- Molecular Weight:172.61
IUPAC Name: (E)-2-((hydroxyimino)methyl)-1-methylpyridin-1-ium chloride
InChIKey: HIGSLXSBYYMVKI-UHFFFAOYSA-N
SMILES: C[N+]1=CC=CC=C1/C=N/O.[Cl-]
Biological Activity: Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning[1][2].
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Pralidoxime chloride | 99.98% | Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning. | ||||||||||||||||||||
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Pralidoxime chloride (Standard) | ≥98% | Pralidoxime (chloride) (Standard) is the analytical standard of Pralidoxime (chloride). This product is intended for research and analytical applications. Pralidoxime chloride is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime chloride reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime chloride is an antidote for organophosphate poisoning. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-B1738Pralidoxime -
Similarity Score 0.96
HY-B1738ARPralidoxime iodide (Standard) -
Similarity Score 0.81
HY-B1738BPralidoxime methanesulfonate -
Similarity Score 0.75
HY-D0216Salicylaldoxime -
Similarity Score 0.73
HY-N0415RTrigonelline chloride (Standard) -
Similarity Score 0.71
HY-W5437264-Carboxy-1-methylpyridin-1-iumchloride -
Similarity Score 0.71
HY-W715341RO-1-5237 -
Similarity Score 0.71
HY-113527RTRIA-662 (Standard) -
Similarity Score 0.70
HY-W1057948(Z)-2-Pyridinecarboxamidoxime -
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References
- [1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [Content Brief]
- [2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [Content Brief]
