1809058-37-4
Chemical Structure
Hypercohin K
- CAS No.: 1809058-37-4
- Formula:C33H40O4
- Molecular Weight:500.68
IUPAC Name: (1aR,6S,7aR)-4-benzoyl-6-((E)-3,7-dimethylocta-2,6-dien-1-yl)-2,2-dimethyl-6-(3-methylbut-2-en-1-yl)-1a,2-dihydro-1H,5H-cyclopropa[c]benzofuran-5,7(6H)-dione
InChIKey: UKPXQYJEQKDSRD-OGZJLKFCSA-N
SMILES: O=C1[C@@]23[C@@](C2)(C(C)(C)OC3=C(C(=O)C4=CC=CC=C4)C(=O)[C@]1(C/C=C(/CCC=C(C)C)\C)CC=C(C)C)[H]
Biological Activity: Hypercohin K is a polycyclic polyprenylated acylphloroglucinol isolated from Hypericum henryi, containing a rare spiro-fused cyclopropane ring in its structure. Hypercohin K exhibits anti-inflammatory, antitumor, and AChE-enhancing activities. Hypercohin K reduces intracellular lipid accumulation by regulating lipid metabolism genes, and can inhibit NO production to exert anti-inflammatory effects. Hypercohin K can be used in research on non-alcoholic steatohepatitis and tumors[1][2][3][4].
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Hypercohin K | Hypercohin K is a polycyclic polyprenylated acylphloroglucinol isolated from Hypericum henryi, containing a rare spiro-fused cyclopropane ring in its structure. Hypercohin K exhibits anti-inflammatory, antitumor, and AChE-enhancing activities. Hypercohin K reduces intracellular lipid accumulation by regulating lipid metabolism genes, and can inhibit NO production to exert anti-inflammatory effects. Hypercohin K can be used in research on non-alcoholic steatohepatitis and tumors. | |||||||||||||||||||||
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References
- [1]. Yang GX, et al. Advanced natural products chemistry research in China between 2015 and 2017. Chin J Nat Med. 2018;16(12):881-906.
- [2]. Yang X W, et al. Hypercohin K, a polycyclic polyprenylated acylphloroglucinol with an unusual spiro-fused cyclopropane ring from Hypericum cohaerens[J]. Tetrahedron Letters, 2015, 56(41): 5537-5540.
- [3]. Lu WJ, et al. Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from . Journal of natural products. 2021 Apr 23;84(4):1135-1148.
- [4]. Yue T, et al. Spirocyclic polycyclic polyprenylated acylphloroglucinols from Hypericum henryi and their anti-inflammatory activity. Fitoterapia. 2026 Jul;192:107277.
