3613-82-9
Chemical Structure
Trimedoxime dichloride
Synonym(s): TMB-4 dichloride
- CAS No.: 3613-82-9
- Formula:C15H18Cl2N4O2
- Molecular Weight:357.24
IUPAC Name: mono(1,1'-(propane-1,3-diyl)bis(4-((E)-(hydroxyimino)methyl)pyridin-1-ium)) monochloride
InChIKey: UTVALPBGSAUYNR-UHFFFAOYSA-N
SMILES: O/N=C/C1=CC=[N+](CCC[N+]2=CC=C(C=C2)/C=N/O)C=C1.[Cl-].[Cl-]
Biological Activity: Trimedoxime dichloride (TMB-4 dichloride) is a blood-brain barrier-permeable cholinesterase reactivator. Trimedoxime dichloride reactivates cholinesterase inhibited by paraoxon, sarin, tabun and other agents, restricts the breakdown of acetylcholine and alleviates excessive cholinergic stimulation. Trimedoxime dichloride reduces mortality and prolongs survival time. Trimedoxime dichloride exhibits reactivation efficacy against AChE in rat tissues. Trimedoxime dichloride can be used in research related to organophosphate (paraoxon) poisoning and tabun poisoning[1][2][3].
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Trimedoxime dichloride | Trimedoxime dichloride (TMB-4 dichloride) is a blood-brain barrier-permeable cholinesterase reactivator. Trimedoxime dichloride reactivates cholinesterase inhibited by paraoxon, sarin, tabun and other agents, restricts the breakdown of acetylcholine and alleviates excessive cholinergic stimulation. Trimedoxime dichloride reduces mortality and prolongs survival time. Trimedoxime dichloride exhibits reactivation efficacy against AChE in rat tissues. Trimedoxime dichloride can be used in research related to organophosphate (paraoxon) poisoning and tabun poisoning. | |||||||||||||||||||||
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- [1]. Petroianu GA, et al. New K-Oximes (K-27 and K-48) in Comparison with Obidoxime (LuH-6), HI-6, Trimedoxime (TMB-4), and Pralidoxime (2-PAM): Survival in Rats Exposed IP to the Organophosphate Paraoxon. Toxicol Mech Methods. 2007;17(7):401-8. [Content Brief]
- [2]. Milic B, et al. Trimedoxime and HI-6: kinetic comparison after intravenous administration to mice. Pharmacol Toxicol. 1996;78(4):269-272. [Content Brief]
- [3]. Kassa J, et al. An evaluation of therapeutic and reactivating effects of newly developed oximes (K156, K203) and commonly used oximes (obidoxime, trimedoxime, HI-6) in tabun-poisoned rats and mice. Toxicology. 2008;243(3):311-316. [Content Brief]
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