1684-40-8
1684-40-8
Chemical Structure
Tacrine hydrochloride
- CAS No.: 1684-40-8
- Formula:C13H15ClN2
- Molecular Weight:234.73
IUPAC Name: 1,2,3,4-tetrahydroacridin-9-amine hydrochloride
InChIKey: ZUFVXZVXEJHHBN-UHFFFAOYSA-N
SMILES: NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl
Biological Activity: Tacrine hydrochloride is a potent brain-penetrant inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease[1][2].
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Tacrine hydrochloride | 99.90% | Tacrine hydrochloride is a potent brain-penetrant inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease. | ||||||||||||||||||||
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Tacrine hydrochloride (Standard) | ≥98% | Tacrine (hydrochloride) (Standard) is the analytical standard of Tacrine (hydrochloride). This product is intended for research and analytical applications. Tacrine hydrochloride is a potent inhibitor of both AChE and BChE, with IC50s of 31 nM and 25.6 nM, respectively. Tacrine hydrochloride is also a NMDAR inhibitor, with an IC50 of 26 μM. Tacrine hydrochloride can be used for the research of Alzheimer’s disease. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.78
HY-W0493127-Methoxytacrine -
Similarity Score 0.78
HY-127165Velnacrine -
Similarity Score 0.76
HY-121886Bucricaine -
Similarity Score 0.69
HY-W0493356,9-Dichloro-1,2,3,4-tetrahydroacridine -
Similarity Score 0.66
HY-W011246Velnacrine maleate -
Similarity Score 0.64
HY-127165SVelnacrine-d3 -
Similarity Score 0.62
HY-W027126Hepatoprotective agent-2 -
Similarity Score 0.61
HY-48957WAY-629450 -
Similarity Score 0.61
HY-103145PNU-22394 hydrochloride -
Explore the MedChemAI to find more analogs
References
- [1]. Ahmed M, et, al. Inhibition of two different cholinesterases by tacrine. Chem Biol Interact. 2006 Aug 25; 162(2):165-71.c [Content Brief]
- [2]. Horak M, et, al. The pharmacology of tacrine at N-methyl-d-aspartate receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2017 Apr 3;75: 54-62. [Content Brief]
