2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Velnacrine maleate

Velnacrine maleate  (Synonyms: HP 029; Hydroxytacrine maleate)

Cat. No.: HY-W011246 Purity: ≥98.0%
COA Handling Instructions

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Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

Velnacrine maleate Chemical Structure

Velnacrine maleate Chemical Structure

CAS No. : 118909-22-1

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25 mg USD 65 In-stock
50 mg USD 110 In-stock
100 mg USD 170 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Velnacrine maleate (HP 029) is an orally active cholinesterase inhibitor that can be used for the research of Alzheimer's disease[1].

Molecular Weight

330.34

Formula

C17H18N2O5
CAS No.
Appearance

Solid

Color

Light yellow to khaki

SMILES

OC(/C=C\C(O)=O)=O.NC1=C2C(CCCC2O)=NC3=CC=CC=C31
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (90.82 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0272 mL 15.1359 mL 30.2718 mL
5 mM 0.6054 mL 3.0272 mL 6.0544 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0272 mL 15.1359 mL 30.2718 mL 75.6796 mL
5 mM 0.6054 mL 3.0272 mL 6.0544 mL 15.1359 mL
10 mM 0.3027 mL 1.5136 mL 3.0272 mL 7.5680 mL
15 mM 0.2018 mL 1.0091 mL 2.0181 mL 5.0453 mL
20 mM 0.1514 mL 0.7568 mL 1.5136 mL 3.7840 mL
25 mM 0.1211 mL 0.6054 mL 1.2109 mL 3.0272 mL
30 mM 0.1009 mL 0.5045 mL 1.0091 mL 2.5227 mL
40 mM 0.0757 mL 0.3784 mL 0.7568 mL 1.8920 mL
50 mM 0.0605 mL 0.3027 mL 0.6054 mL 1.5136 mL
60 mM 0.0505 mL 0.2523 mL 0.5045 mL 1.2613 mL
80 mM 0.0378 mL 0.1892 mL 0.3784 mL 0.9460 mL
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Velnacrine maleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Velnacrine118909-22-1HP 029HydroxytacrineHP029HP-029Cholinesterase (ChE)Alzheimer's diseaseInhibitorinhibitorinhibit

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