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Cat. No.: HY-124421R

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5F-203 (Standard)

Name: 5F-203 (Standard)
Brand: MedChemExpress
SKU: HY-124421R
Price: 180.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: NSC-703786 (Standard))

5F-203 (Standard) (NSC-703786 (Standard)) is the analytical standard of 5F-203 (HY-124421). This product is intended for research and analytical applications. 5F-203 (NSC-703786) is an aryl hydrocarbon receptor (AhR) agonist and the active moiety of the water-soluble benzothiazole prodrug Phortress (HY-103223). 5F-203 binds to cytosolic AhR and induces CYP1A1 and CYP1B1 expression. 5F-203 activates AhR signaling to induce DNA damage, cell cycle arrest, apoptosis, caspase-3/-7 activation, lysosomal membrane permeabilization, and Cathepsin B release. 5F-203 induces CYGB and pro-apoptotic protein expression and NAG-1 mRNA/protein induction through RNA stabilization. 5F-203 is used in research related to cancers such as triple-negative breast cancer and colorectal cancer.

For research use only. We do not sell to patients.

Purity : 95%
CAS No.: 260443-89-8
Formula: C₁₄H₁₁FN₂S
Molecular Weight:258.32

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

5F-203 (Standard) Chemical Structure

CAS No.: 260443-89-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 260443-89-8
Molecular Weight 258.32
Formula C₁₄H₁₁FN₂S
SMILES

NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C
Synonyms

NSC-703786 (Standard)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Peters G, et al. The role of pharmacology in anticancer drug development. ADMET and DMPK. 2018 Mar 25;6(1):4-14.

[2]. Rowland LK, et al. Putative tumor suppressor cytoglobin promotes aryl hydrocarbon receptor ligand-mediated triple negative breast cancer cell death. Journal of cellular biochemistry. 2019 Apr;120(4):6004-6014.

[3]. Ohashi T, et al. ZSTK3744, a Novel Aryl Hydrocarbon Receptor Agonist, Exhibits Efficacy against Chemotherapy-Resistant Triple-Negative Breast Cancer. Cancer research communications. 2026 Feb 01;6(2):421-436. [Content Brief]

[4]. Baek SJ, et al. Changes in gene expression contribute to cancer prevention by COX inhibitors. Progress in lipid research. 2006 Jan;45(1):1-16.

[5]. Eling TE, et al. NSAID activated gene (NAG-1), a modulator of tumorigenesis. Journal of biochemistry and molecular biology. 2006 Nov 30;39(6):649-55.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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