260443-89-8
260443-89-8
Chemical Structure
5F-203
Synonym(s): NSC-703786
- CAS No.: 260443-89-8
- Formula:C14H11FN2S
- Molecular Weight:258.31
IUPAC Name: 4-(5-fluorobenzo[d]thiazol-2-yl)-2-methylaniline
InChIKey: IFWLHIIUGSEKKE-UHFFFAOYSA-N
SMILES: NC1=CC=C(C2=NC3=CC(F)=CC=C3S2)C=C1C
Biological Activity: 5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5F-203 | 98.04% | 5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38. | ||||||||||||||||||||
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5F-203 (Standard) | ≥98% | 5F-203 (Standard) is the analytical standard of 5F-203. This product is intended for research and analytical applications. 5F-203 (NSC-703786) is a cytotoxic molecule that forms DNA adducts and cell cycle arrest. 5F-203 induces aryl hydrocarbon receptor (AhR) signaling and elevates expression of CYP1A1. 5F-203 also increases the levels of reactive oxygen species as well as activates JNK, ERK, and p38. | ||||||||||||||||||||
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References
- [1]. Hutchinson I, et al. Antitumor benzothiazoles. 16. Synthesis and pharmaceutical properties of antitumor 2-(4-aminophenyl)benzothiazole amino acid prodrugs. J Med Chem. 2002 Jan 31;45(3):744-7. [Content Brief]
- [2]. Hose CD, et al. Induction of CYP1A1 in tumor cells by the antitumor agent 2-[4-amino-3-methylphenyl]-5-fluoro-benzothiazole: a potential surrogate marker for patient sensitivity. Mol Cancer Ther. 2003 Dec;2(12):1265-72. [Content Brief]
- [3]. Callero MA, et al. Biomarkers of sensitivity to potent and selective antitumor 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F203) in ovarian cancer. J Cell Biochem. 2013 Oct;114(10):2392-404. [Content Brief]
Keywords
